BDBM50190465 1-(4-(4-aminophenyl)butyl)-3-(3,5-diamino-2-chloropyrazine-6-carbonyl)guanidine::CHEMBL212410

SMILES: NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(N)cc1

InChI Key: InChIKey=KOKWQVJPVOHNKZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50190465   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Amiloride-sensitive sodium channel alpha-subunit (Homo sapiens (Human))	BDBM50190465 (1-(4-(4-aminophenyl)butyl)-3-(3,5-diamino-2-chloro...) Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(N)cc1 |w:14.15| Show InChI InChI=1S/C16H21ClN8O/c17-12-14(20)24-13(19)11(23-12)15(26)25-16(21)22-8-2-1-3-9-4-6-10(18)7-5-9/h4-7H,1-3,8,18H2,(H4,19,20,24)(H3,21,22,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Parion Sciences Inc. Curated by ChEMBL					Assay Description Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay				J Med Chem 49: 4098-115 (2006) Article DOI: 10.1021/jm051134w BindingDB Entry DOI: 10.7270/Q2FT8KNH
					More data for this Ligand-Target Pair