BDBM50191510 2-[4-(4'-chloro-5-dimethylcarbamoylbiphenyl-2-ylmethoxy)-phenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid::CHEMBL378218

SMILES: CN(C)C(=O)c1ccc(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c(c1)-c1ccc(Cl)cc1

InChI Key: InChIKey=UXRKKYJFCINMEN-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50191510   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatitis C virus NS5B RNA-dependent RNA polymerase (Hepatitis C virus)	BDBM50191510 (2-[4-(4'-chloro-5-dimethylcarbamoylbiphenyl-2-ylme...) Show SMILES CN(C)C(=O)c1ccc(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c(c1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C36H34ClN3O4/c1-39(2)35(41)25-8-9-27(31(20-25)23-10-15-28(37)16-11-23)22-44-30-17-12-24(13-18-30)34-38-32-21-26(36(42)43)14-19-33(32)40(34)29-6-4-3-5-7-29/h8-21,29H,3-7,22H2,1-2H3,(H,42,43)	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Central Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase				J Med Chem 49: 4721-36 (2006) Article DOI: 10.1021/jm060269e BindingDB Entry DOI: 10.7270/Q2FN15TD
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus genotype 1)	BDBM50191510 (2-[4-(4'-chloro-5-dimethylcarbamoylbiphenyl-2-ylme...) Show SMILES CN(C)C(=O)c1ccc(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c(c1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C36H34ClN3O4/c1-39(2)35(41)25-8-9-27(31(20-25)23-10-15-28(37)16-11-23)22-44-30-17-12-24(13-18-30)34-38-32-21-26(36(42)43)14-19-33(32)40(34)29-6-4-3-5-7-29/h8-21,29H,3-7,22H2,1-2H3,(H,42,43)	UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min				Citation and Details Article DOI: 10.1007/s00044-012-0186-8 BindingDB Entry DOI: 10.7270/Q2NC6441
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus genotype 1)	BDBM50191510 (2-[4-(4'-chloro-5-dimethylcarbamoylbiphenyl-2-ylme...) Show SMILES CN(C)C(=O)c1ccc(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c(c1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C36H34ClN3O4/c1-39(2)35(41)25-8-9-27(31(20-25)23-10-15-28(37)16-11-23)22-44-30-17-12-24(13-18-30)34-38-32-21-26(36(42)43)14-19-33(32)40(34)29-6-4-3-5-7-29/h8-21,29H,3-7,22H2,1-2H3,(H,42,43)	UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	3.13E+7	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min				Citation and Details Article DOI: 10.1007/s00044-012-0186-8 BindingDB Entry DOI: 10.7270/Q2NC6441
					More data for this Ligand-Target Pair