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BDBM50191773 CHEMBL3908516

SMILES: c1nc2cnc3cnc(cc3c2n1-c1ccc2ncccc2c1)-c1ccccc1

InChI Key: InChIKey=KUUOKLYDLXUISS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50191773   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50191773
PNG
(CHEMBL3908516)
Show SMILES c1nc2cnc3cnc(cc3c2n1-c1ccc2ncccc2c1)-c1ccccc1
Show InChI InChI=1S/C24H15N5/c1-2-5-16(6-3-1)21-12-19-22(13-26-21)27-14-23-24(19)29(15-28-23)18-8-9-20-17(11-18)7-4-10-25-20/h1-15H
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 96n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human COT (66 to 395 residues) expressed in Sf21 cells using 5-Fluo-Ahx-AGAGSGQLIDSNleANSFVGTR-NH2 as substrate after 60 mins by calipe...


J Med Chem 59: 7544-60 (2016)


BindingDB Entry DOI: 10.7270/Q29P33MR
More data for this
Ligand-Target Pair