BDBM50191911 CHEMBL212908::trans-N1-(4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)cyclohexane-1,4-diamine

SMILES: Cc1[nH]c2ncccc2c1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1

InChI Key: InChIKey=UVNBSIVBIHIMGX-JOCQHMNTSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50191911   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3 (Homo sapiens (Human))	BDBM50191911 (CHEMBL212908 | trans-N1-(4-(2-methyl-1H-pyrrolo[2,...) Show SMILES Cc1[nH]c2ncccc2c1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1 |wU:16.17,wD:19.21,(24.73,-47.38,;23.59,-46.35,;22.08,-46.68,;21.31,-45.35,;19.82,-45.03,;19.34,-43.58,;20.37,-42.44,;21.87,-42.76,;22.34,-44.21,;23.74,-44.84,;25.07,-44.07,;25.07,-42.53,;26.41,-41.76,;27.73,-42.53,;27.73,-44.07,;29.07,-44.84,;30.41,-44.07,;30.4,-42.52,;31.76,-41.76,;33.1,-42.55,;34.44,-41.79,;33.08,-44.1,;31.73,-44.86,;26.41,-44.84,)| Show InChI InChI=1S/C18H22N6/c1-11-16(14-3-2-9-20-17(14)22-11)15-8-10-21-18(24-15)23-13-6-4-12(19)5-7-13/h2-3,8-10,12-13H,4-7,19H2,1H3,(H,20,22)(H,21,23,24)/t12-,13-	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of CDK1/cyclinB by Flashplate assay				Bioorg Med Chem Lett 16: 4818-21 (2006) Article DOI: 10.1016/j.bmcl.2006.06.073 BindingDB Entry DOI: 10.7270/Q2571BNM
					More data for this Ligand-Target Pair