BDBM50192127 2-(ethyl(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)amino)-N,N-dimethyl-2-phenylpropanamide::CHEMBL214948

SMILES: CCN(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(C)(C(=O)N(C)C)c1ccccc1

InChI Key: InChIKey=OYDVTUOOJHLOCO-UHFFFAOYSA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50192127   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM50192127 (2-(ethyl(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan...) Show SMILES CCN(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(C)(C(=O)N(C)C)c1ccccc1 Show InChI InChI=1S/C22H24F6N2O2/c1-5-30(19(2,18(31)29(3)4)15-9-7-6-8-10-15)17-13-11-16(12-14-17)20(32,21(23,24)25)22(26,27)28/h6-14,32H,5H2,1-4H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Transactivation of LXRalpha by luciferase reporter gene assay				Bioorg Med Chem Lett 16: 5231-7 (2006) Article DOI: 10.1016/j.bmcl.2006.06.081 BindingDB Entry DOI: 10.7270/Q2HD7V80
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM50192127 (2-(ethyl(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan...) Show SMILES CCN(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(C)(C(=O)N(C)C)c1ccccc1 Show InChI InChI=1S/C22H24F6N2O2/c1-5-30(19(2,18(31)29(3)4)15-9-7-6-8-10-15)17-13-11-16(12-14-17)20(32,21(23,24)25)22(26,27)28/h6-14,32H,5H2,1-4H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Binding affinity to LXRalpha by radioligand displacement assay				Bioorg Med Chem Lett 16: 5231-7 (2006) Article DOI: 10.1016/j.bmcl.2006.06.081 BindingDB Entry DOI: 10.7270/Q2HD7V80
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM50192127 (2-(ethyl(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan...) Show SMILES CCN(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(C)(C(=O)N(C)C)c1ccccc1 Show InChI InChI=1S/C22H24F6N2O2/c1-5-30(19(2,18(31)29(3)4)15-9-7-6-8-10-15)17-13-11-16(12-14-17)20(32,21(23,24)25)22(26,27)28/h6-14,32H,5H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Transactivation of LXRbeta by luciferase reporter gene assay				Bioorg Med Chem Lett 16: 5231-7 (2006) Article DOI: 10.1016/j.bmcl.2006.06.081 BindingDB Entry DOI: 10.7270/Q2HD7V80
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM50192127 (2-(ethyl(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan...) Show SMILES CCN(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(C)(C(=O)N(C)C)c1ccccc1 Show InChI InChI=1S/C22H24F6N2O2/c1-5-30(19(2,18(31)29(3)4)15-9-7-6-8-10-15)17-13-11-16(12-14-17)20(32,21(23,24)25)22(26,27)28/h6-14,32H,5H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Binding affinity to LXRbeta by radioligand displacement assay				Bioorg Med Chem Lett 16: 5231-7 (2006) Article DOI: 10.1016/j.bmcl.2006.06.081 BindingDB Entry DOI: 10.7270/Q2HD7V80
					More data for this Ligand-Target Pair