BDBM50192220 CHEMBL384175::ethyl 3-(4-tert-butylphenyl)-4-cyano-5-(methylthio)thiophene-2-carboxylate

SMILES: CCOC(=O)c1sc(SC)c(C#N)c1-c1ccc(cc1)C(C)(C)C

InChI Key: InChIKey=ITBKXYIQENUVSN-UHFFFAOYSA-N

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50192220   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GRIA2 (Homo sapiens (Human))	BDBM50192220 (CHEMBL384175 | ethyl 3-(4-tert-butylphenyl)-4-cyan...) Show SMILES CCOC(=O)c1sc(SC)c(C#N)c1-c1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C19H21NO2S2/c1-6-22-17(21)16-15(14(11-20)18(23-5)24-16)12-7-9-13(10-8-12)19(2,3)4/h7-10H,6H2,1-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a
Lilly S.A. Curated by ChEMBL					Assay Description Activity against human GLUR2 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay				Bioorg Med Chem Lett 16: 5057-61 (2006) Article DOI: 10.1016/j.bmcl.2006.07.035 BindingDB Entry DOI: 10.7270/Q24749H7
					More data for this Ligand-Target Pair
GRIA2 (Homo sapiens (Human))	BDBM50192220 (CHEMBL384175 | ethyl 3-(4-tert-butylphenyl)-4-cyan...) Show SMILES CCOC(=O)c1sc(SC)c(C#N)c1-c1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C19H21NO2S2/c1-6-22-17(21)16-15(14(11-20)18(23-5)24-16)12-7-9-13(10-8-12)19(2,3)4/h7-10H,6H2,1-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a
Lilly S.A. Curated by ChEMBL					Assay Description Activity against human GLUR2 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay				Bioorg Med Chem Lett 16: 5057-61 (2006) Article DOI: 10.1016/j.bmcl.2006.07.035 BindingDB Entry DOI: 10.7270/Q24749H7
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50192220 (CHEMBL384175 | ethyl 3-(4-tert-butylphenyl)-4-cyan...) Show SMILES CCOC(=O)c1sc(SC)c(C#N)c1-c1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C19H21NO2S2/c1-6-22-17(21)16-15(14(11-20)18(23-5)24-16)12-7-9-13(10-8-12)19(2,3)4/h7-10H,6H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a
Lilly S.A. Curated by ChEMBL					Assay Description Activity against human GLUR4 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay				Bioorg Med Chem Lett 16: 5057-61 (2006) Article DOI: 10.1016/j.bmcl.2006.07.035 BindingDB Entry DOI: 10.7270/Q24749H7
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50192220 (CHEMBL384175 | ethyl 3-(4-tert-butylphenyl)-4-cyan...) Show SMILES CCOC(=O)c1sc(SC)c(C#N)c1-c1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C19H21NO2S2/c1-6-22-17(21)16-15(14(11-20)18(23-5)24-16)12-7-9-13(10-8-12)19(2,3)4/h7-10H,6H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a
Lilly S.A. Curated by ChEMBL					Assay Description Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay				Bioorg Med Chem Lett 16: 5057-61 (2006) Article DOI: 10.1016/j.bmcl.2006.07.035 BindingDB Entry DOI: 10.7270/Q24749H7
					More data for this Ligand-Target Pair