BDBM50192290 CHEMBL379337::N-[(5R,6R,8R,9R)-6-benzyloxymethyl-9-(tert-butyl-dimethyl-silanyloxy)-8-(3,5-dimethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-4-yl]-oxalamic acid methyl ester

SMILES: COC(=O)C(=O)NC1=CS(=O)(=O)O[C@@]11[C@@H](COCc2ccccc2)O[C@H]([C@@H]1O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)n(C)c1=O

InChI Key: InChIKey=IBGNZFRSKQGACX-XUWZGWRCSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50192290   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50192290 (CHEMBL379337 | N-[(5R,6R,8R,9R)-6-benzyloxymethyl-...) Show SMILES COC(=O)C(=O)NC1=CS(=O)(=O)O[C@@]11[C@@H](COCc2ccccc2)O[C@H]([C@@H]1O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)n(C)c1=O |t:7| Show InChI InChI=1S/C29H39N3O11SSi/c1-18-14-32(27(36)31(5)24(18)34)25-22(42-45(7,8)28(2,3)4)29(21(41-25)16-40-15-19-12-10-9-11-13-19)20(17-44(37,38)43-29)30-23(33)26(35)39-6/h9-14,17,21-22,25H,15-16H2,1-8H3,(H,30,33)/t21-,22+,25-,29-/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh School of Medicine Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase RNA-dependent DNA polymerase activity				J Med Chem 49: 4834-41 (2006) Article DOI: 10.1021/jm0604575 BindingDB Entry DOI: 10.7270/Q2GH9HKC
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50192290 (CHEMBL379337 | N-[(5R,6R,8R,9R)-6-benzyloxymethyl-...) Show SMILES COC(=O)C(=O)NC1=CS(=O)(=O)O[C@@]11[C@@H](COCc2ccccc2)O[C@H]([C@@H]1O[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)n(C)c1=O |t:7| Show InChI InChI=1S/C29H39N3O11SSi/c1-18-14-32(27(36)31(5)24(18)34)25-22(42-45(7,8)28(2,3)4)29(21(41-25)16-40-15-19-12-10-9-11-13-19)20(17-44(37,38)43-29)30-23(33)26(35)39-6/h9-14,17,21-22,25H,15-16H2,1-8H3,(H,30,33)/t21-,22+,25-,29-/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh School of Medicine Curated by ChEMBL					Assay Description Inhibition of FLAG-p66/HIS-p51-mediated HIV1 reverse transcriptase dimerization				J Med Chem 49: 4834-41 (2006) Article DOI: 10.1021/jm0604575 BindingDB Entry DOI: 10.7270/Q2GH9HKC
					More data for this Ligand-Target Pair