BDBM50192350 9-hydroxy-4,5-diphenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione::CHEMBL385047

SMILES: Oc1ccc2[nH]c3c(-c4ccccc4)c(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1

InChI Key: InChIKey=DQBYFQXXFBDIBM-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50192350   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50192350 (9-hydroxy-4,5-diphenylpyrrolo[3,4-c]carbazole-1,3(...) Show SMILES Oc1ccc2[nH]c3c(-c4ccccc4)c(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1 Show InChI InChI=1S/C26H16N2O3/c29-16-11-12-18-17(13-16)21-23-22(25(30)28-26(23)31)19(14-7-3-1-4-8-14)20(24(21)27-18)15-9-5-2-6-10-15/h1-13,27,29H,(H,28,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition at human Chk1 in presence of 4 uM ATP				J Med Chem 49: 4896-911 (2006) Article DOI: 10.1021/jm0512591 BindingDB Entry DOI: 10.7270/Q23778BD
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50192350 (9-hydroxy-4,5-diphenylpyrrolo[3,4-c]carbazole-1,3(...) Show SMILES Oc1ccc2[nH]c3c(-c4ccccc4)c(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1 Show InChI InChI=1S/C26H16N2O3/c29-16-11-12-18-17(13-16)21-23-22(25(30)28-26(23)31)19(14-7-3-1-4-8-14)20(24(21)27-18)15-9-5-2-6-10-15/h1-13,27,29H,(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chulalongkorn University Curated by ChEMBL					Assay Description Inhibition of human Wee1				Eur J Med Chem 44: 1383-95 (2009) Article DOI: 10.1016/j.ejmech.2008.09.027 BindingDB Entry DOI: 10.7270/Q2X34XB6
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50192350 (9-hydroxy-4,5-diphenylpyrrolo[3,4-c]carbazole-1,3(...) Show SMILES Oc1ccc2[nH]c3c(-c4ccccc4)c(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1 Show InChI InChI=1S/C26H16N2O3/c29-16-11-12-18-17(13-16)21-23-22(25(30)28-26(23)31)19(14-7-3-1-4-8-14)20(24(21)27-18)15-9-5-2-6-10-15/h1-13,27,29H,(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of human Wee1 in presence of 9.5 uM ATP				J Med Chem 49: 4896-911 (2006) Article DOI: 10.1021/jm0512591 BindingDB Entry DOI: 10.7270/Q23778BD
					More data for this Ligand-Target Pair