BDBM50192372 4-(2-chlorophenyl)-9-hydroxy-1H-[1]benzofuro[3,2-e]isoindole-1,3(2H)-dione::4-(2-chlorophenyl)-9-hydroxy-1H-benzofuro[3,2-e]isoindole-1,3(2H)-dione::CHEMBL386398

SMILES: Oc1ccc2oc3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl

InChI Key: InChIKey=KGAPFKLOTLAAMY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50192372   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50192372 (4-(2-chlorophenyl)-9-hydroxy-1H-[1]benzofuro[3,2-e...) Show SMILES Oc1ccc2oc3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl Show InChI InChI=1S/C20H10ClNO4/c21-13-4-2-1-3-10(13)11-8-15-16(18-17(11)19(24)22-20(18)25)12-7-9(23)5-6-14(12)26-15/h1-8,23H,(H,22,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition at human Chk1 in presence of 4 uM ATP				J Med Chem 49: 4896-911 (2006) Article DOI: 10.1021/jm0512591 BindingDB Entry DOI: 10.7270/Q23778BD
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50192372 (4-(2-chlorophenyl)-9-hydroxy-1H-[1]benzofuro[3,2-e...) Show SMILES Oc1ccc2oc3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl Show InChI InChI=1S/C20H10ClNO4/c21-13-4-2-1-3-10(13)11-8-15-16(18-17(11)19(24)22-20(18)25)12-7-9(23)5-6-14(12)26-15/h1-8,23H,(H,22,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Chulalongkorn University Curated by ChEMBL					Assay Description Inhibition of human Wee1				Eur J Med Chem 44: 1383-95 (2009) Article DOI: 10.1016/j.ejmech.2008.09.027 BindingDB Entry DOI: 10.7270/Q2X34XB6
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50192372 (4-(2-chlorophenyl)-9-hydroxy-1H-[1]benzofuro[3,2-e...) Show SMILES Oc1ccc2oc3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl Show InChI InChI=1S/C20H10ClNO4/c21-13-4-2-1-3-10(13)11-8-15-16(18-17(11)19(24)22-20(18)25)12-7-9(23)5-6-14(12)26-15/h1-8,23H,(H,22,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of human Wee1 in presence of 9.5 uM ATP				J Med Chem 49: 4896-911 (2006) Article DOI: 10.1021/jm0512591 BindingDB Entry DOI: 10.7270/Q23778BD
					More data for this Ligand-Target Pair