BDBM50192439 4-(2,3-dimethylphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione::CHEMBL212945

SMILES: Cc1cccc(c1C)-c1cc2[nH]c3ccc(O)cc3c2c2C(=O)NC(=O)c12

InChI Key: InChIKey=GITAHVASPSHUFI-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50192439   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50192439 (4-(2,3-dimethylphenyl)-9-hydroxypyrrolo[3,4-c]carb...) Show SMILES Cc1cccc(c1C)-c1cc2[nH]c3ccc(O)cc3c2c2C(=O)NC(=O)c12 Show InChI InChI=1S/C22H16N2O3/c1-10-4-3-5-13(11(10)2)14-9-17-18(20-19(14)21(26)24-22(20)27)15-8-12(25)6-7-16(15)23-17/h3-9,23,25H,1-2H3,(H,24,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition at human Chk1 in presence of 4 uM ATP				J Med Chem 49: 4896-911 (2006) Article DOI: 10.1021/jm0512591 BindingDB Entry DOI: 10.7270/Q23778BD
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50192439 (4-(2,3-dimethylphenyl)-9-hydroxypyrrolo[3,4-c]carb...) Show SMILES Cc1cccc(c1C)-c1cc2[nH]c3ccc(O)cc3c2c2C(=O)NC(=O)c12 Show InChI InChI=1S/C22H16N2O3/c1-10-4-3-5-13(11(10)2)14-9-17-18(20-19(14)21(26)24-22(20)27)15-8-12(25)6-7-16(15)23-17/h3-9,23,25H,1-2H3,(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Chulalongkorn University Curated by ChEMBL					Assay Description Inhibition of human Wee1				Eur J Med Chem 44: 1383-95 (2009) Article DOI: 10.1016/j.ejmech.2008.09.027 BindingDB Entry DOI: 10.7270/Q2X34XB6
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50192439 (4-(2,3-dimethylphenyl)-9-hydroxypyrrolo[3,4-c]carb...) Show SMILES Cc1cccc(c1C)-c1cc2[nH]c3ccc(O)cc3c2c2C(=O)NC(=O)c12 Show InChI InChI=1S/C22H16N2O3/c1-10-4-3-5-13(11(10)2)14-9-17-18(20-19(14)21(26)24-22(20)27)15-8-12(25)6-7-16(15)23-17/h3-9,23,25H,1-2H3,(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of human Wee1 in presence of 9.5 uM ATP				J Med Chem 49: 4896-911 (2006) Article DOI: 10.1021/jm0512591 BindingDB Entry DOI: 10.7270/Q23778BD
					More data for this Ligand-Target Pair