BDBM50192470 (3-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-3-methyl-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine::CHEMBL386052
SMILES: COc1cc2CNc3c(Nc4cccc(Cl)c4F)nc(C)nc3Oc2cc1OC
InChI Key: InChIKey=MTSNGHVNGCZYBV-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50192470 ((3-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-3-methyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc Curated by ChEMBL | Assay Description Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay | Bioorg Med Chem Lett 16: 5102-6 (2006) Article DOI: 10.1016/j.bmcl.2006.07.031 BindingDB Entry DOI: 10.7270/Q2K9374T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50192470 ((3-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-3-methyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc Curated by ChEMBL | Assay Description Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay | Bioorg Med Chem Lett 16: 5102-6 (2006) Article DOI: 10.1016/j.bmcl.2006.07.031 BindingDB Entry DOI: 10.7270/Q2K9374T | |||||||||||
More data for this Ligand-Target Pair |