BDBM50192559 (R)-4-(2-oxo-2,3-dihydroimidazo[4,5-b]pyridin-1-yl)-N-(2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)piperidine-1-carboxamide::CHEMBL408093

SMILES: FC(F)(F)CN1c2ccccc2C(=N[C@@H](NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)C1=O)c1ccccc1

InChI Key: InChIKey=LFOJHJKDMPMMQY-VWLOTQADSA-N

Data: 2 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50192559   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50192559 ((R)-4-(2-oxo-2,3-dihydroimidazo[4,5-b]pyridin-1-yl...) Show SMILES FC(F)(F)CN1c2ccccc2C(=N[C@@H](NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)C1=O)c1ccccc1 |r,c:13| Show InChI InChI=1S/C29H26F3N7O3/c30-29(31,32)17-38-21-10-5-4-9-20(21)23(18-7-2-1-3-8-18)34-25(26(38)40)36-27(41)37-15-12-19(13-16-37)39-22-11-6-14-33-24(22)35-28(39)42/h1-11,14,19,25H,12-13,15-17H2,(H,36,41)(H,33,35,42)/t25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co Curated by ChEMBL					Assay Description Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1				Bioorg Med Chem Lett 19: 214-7 (2008) Article DOI: 10.1016/j.bmcl.2008.10.106 BindingDB Entry DOI: 10.7270/Q21C1XSK
					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50192559 ((R)-4-(2-oxo-2,3-dihydroimidazo[4,5-b]pyridin-1-yl...) Show SMILES FC(F)(F)CN1c2ccccc2C(=N[C@@H](NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)C1=O)c1ccccc1 |r,c:13| Show InChI InChI=1S/C29H26F3N7O3/c30-29(31,32)17-38-21-10-5-4-9-20(21)23(18-7-2-1-3-8-18)34-25(26(38)40)36-27(41)37-15-12-19(13-16-37)39-22-11-6-14-33-24(22)35-28(39)42/h1-11,14,19,25H,12-13,15-17H2,(H,36,41)(H,33,35,42)/t25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]CGRP from human recombinant CGRP receptor				Bioorg Med Chem Lett 16: 5052-6 (2006) Article DOI: 10.1016/j.bmcl.2006.07.044 BindingDB Entry DOI: 10.7270/Q29S1QNX
					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50192559 ((R)-4-(2-oxo-2,3-dihydroimidazo[4,5-b]pyridin-1-yl...) Show SMILES FC(F)(F)CN1c2ccccc2C(=N[C@@H](NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)C1=O)c1ccccc1 |r,c:13| Show InChI InChI=1S/C29H26F3N7O3/c30-29(31,32)17-38-21-10-5-4-9-20(21)23(18-7-2-1-3-8-18)34-25(26(38)40)36-27(41)37-15-12-19(13-16-37)39-22-11-6-14-33-24(22)35-28(39)42/h1-11,14,19,25H,12-13,15-17H2,(H,36,41)(H,33,35,42)/t25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co Curated by ChEMBL					Assay Description Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production				Bioorg Med Chem Lett 19: 214-7 (2008) Article DOI: 10.1016/j.bmcl.2008.10.106 BindingDB Entry DOI: 10.7270/Q21C1XSK
					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50192559 ((R)-4-(2-oxo-2,3-dihydroimidazo[4,5-b]pyridin-1-yl...) Show SMILES FC(F)(F)CN1c2ccccc2C(=N[C@@H](NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)C1=O)c1ccccc1 |r,c:13| Show InChI InChI=1S/C29H26F3N7O3/c30-29(31,32)17-38-21-10-5-4-9-20(21)23(18-7-2-1-3-8-18)34-25(26(38)40)36-27(41)37-15-12-19(13-16-37)39-22-11-6-14-33-24(22)35-28(39)42/h1-11,14,19,25H,12-13,15-17H2,(H,36,41)(H,33,35,42)/t25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production				Bioorg Med Chem Lett 16: 5052-6 (2006) Article DOI: 10.1016/j.bmcl.2006.07.044 BindingDB Entry DOI: 10.7270/Q29S1QNX
					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50192559 ((R)-4-(2-oxo-2,3-dihydroimidazo[4,5-b]pyridin-1-yl...) Show SMILES FC(F)(F)CN1c2ccccc2C(=N[C@@H](NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)C1=O)c1ccccc1 |r,c:13| Show InChI InChI=1S/C29H26F3N7O3/c30-29(31,32)17-38-21-10-5-4-9-20(21)23(18-7-2-1-3-8-18)34-25(26(38)40)36-27(41)37-15-12-19(13-16-37)39-22-11-6-14-33-24(22)35-28(39)42/h1-11,14,19,25H,12-13,15-17H2,(H,36,41)(H,33,35,42)/t25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co Curated by ChEMBL					Assay Description Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in p...				Bioorg Med Chem Lett 19: 214-7 (2008) Article DOI: 10.1016/j.bmcl.2008.10.106 BindingDB Entry DOI: 10.7270/Q21C1XSK
					More data for this Ligand-Target Pair