BDBM50192831 CHEMBL3895104::US10188627, Compound 8h

SMILES: CC(CCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CCC(O)=O

InChI Key: InChIKey=VGCXWBRYLPTPQG-UHFFFAOYSA-N

Data: 9 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50192831   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50192831 (CHEMBL3895104 | US10188627, Compound 8h) Show SMILES CC(CCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CCC(O)=O Show InChI InChI=1S/C26H29NO5/c1-19(9-14-25(28)29)15-17-32-24-7-4-3-6-22(24)18-27(2)26(30)21-12-10-20(11-13-21)23-8-5-16-31-23/h3-8,10-13,16,19H,9,14-15,17-18H2,1-2H3,(H,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	998	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Transactivation of human Gal4-PPARdelta LBD transfected in African green monkey CV1 cells after 24 hrs by luciferase reporter gene assay				ACS Med Chem Lett 7: 824-5 (2016) Article DOI: 10.1021/acsmedchemlett.6b00301 BindingDB Entry DOI: 10.7270/Q2WH2RZ8
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50192831 (CHEMBL3895104 | US10188627, Compound 8h) Show SMILES CC(CCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CCC(O)=O Show InChI InChI=1S/C26H29NO5/c1-19(9-14-25(28)29)15-17-32-24-7-4-3-6-22(24)18-27(2)26(30)21-12-10-20(11-13-21)23-8-5-16-31-23/h3-8,10-13,16,19H,9,14-15,17-18H2,1-2H3,(H,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Transactivation of ProLink tagged human PPARdelta transfected in CHO-K1 cells assessed as interaction with EA labelled SRCP after 3 to 16 hrs by beta...				ACS Med Chem Lett 7: 824-5 (2016) Article DOI: 10.1021/acsmedchemlett.6b00301 BindingDB Entry DOI: 10.7270/Q2WH2RZ8
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50192831 (CHEMBL3895104 | US10188627, Compound 8h) Show SMILES CC(CCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CCC(O)=O Show InChI InChI=1S/C26H29NO5/c1-19(9-14-25(28)29)15-17-32-24-7-4-3-6-22(24)18-27(2)26(30)21-12-10-20(11-13-21)23-8-5-16-31-23/h3-8,10-13,16,19H,9,14-15,17-18H2,1-2H3,(H,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	40.2	n/a	n/a	n/a	n/a
Mitobridge, Inc.; Salk Institute for Biological Studies US Patent					Assay Description Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...				US Patent US10188627 (2019) BindingDB Entry DOI: 10.7270/Q2HX1FR6
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50192831 (CHEMBL3895104 | US10188627, Compound 8h) Show SMILES CC(CCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CCC(O)=O Show InChI InChI=1S/C26H29NO5/c1-19(9-14-25(28)29)15-17-32-24-7-4-3-6-22(24)18-27(2)26(30)21-12-10-20(11-13-21)23-8-5-16-31-23/h3-8,10-13,16,19H,9,14-15,17-18H2,1-2H3,(H,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	998	n/a	n/a	n/a	n/a
Mitobridge, Inc.; Salk Institute for Biological Studies US Patent					Assay Description Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...				US Patent US10188627 (2019) BindingDB Entry DOI: 10.7270/Q2HX1FR6
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM50192831 (CHEMBL3895104 | US10188627, Compound 8h) Show SMILES CC(CCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CCC(O)=O Show InChI InChI=1S/C26H29NO5/c1-19(9-14-25(28)29)15-17-32-24-7-4-3-6-22(24)18-27(2)26(30)21-12-10-20(11-13-21)23-8-5-16-31-23/h3-8,10-13,16,19H,9,14-15,17-18H2,1-2H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Mitobridge, Inc. Curated by ChEMBL					Assay Description Activation of human PPARgamma LBD expressed in CHO-K1 cells by beta galactosidase enzyme fragment complement based fluorescence assay				Bioorg Med Chem Lett 27: 5230-5234 (2017) Article DOI: 10.1016/j.bmcl.2017.10.037 BindingDB Entry DOI: 10.7270/Q21V5HJT
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM50192831 (CHEMBL3895104 | US10188627, Compound 8h) Show SMILES CC(CCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CCC(O)=O Show InChI InChI=1S/C26H29NO5/c1-19(9-14-25(28)29)15-17-32-24-7-4-3-6-22(24)18-27(2)26(30)21-12-10-20(11-13-21)23-8-5-16-31-23/h3-8,10-13,16,19H,9,14-15,17-18H2,1-2H3,(H,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	990	n/a	n/a	n/a	n/a
Mitobridge, Inc. Curated by ChEMBL					Assay Description Transactivation of yeast GAL4 DNA binding domain-fused PPARdelta LBD (unknown origin) expressed in CV-1 cells after 24 hrs by luciferase reporter gen...				Bioorg Med Chem Lett 27: 5230-5234 (2017) Article DOI: 10.1016/j.bmcl.2017.10.037 BindingDB Entry DOI: 10.7270/Q21V5HJT
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM50192831 (CHEMBL3895104 | US10188627, Compound 8h) Show SMILES CC(CCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CCC(O)=O Show InChI InChI=1S/C26H29NO5/c1-19(9-14-25(28)29)15-17-32-24-7-4-3-6-22(24)18-27(2)26(30)21-12-10-20(11-13-21)23-8-5-16-31-23/h3-8,10-13,16,19H,9,14-15,17-18H2,1-2H3,(H,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Mitobridge, Inc. Curated by ChEMBL					Assay Description Activation of human PPARdelta LBD expressed in CHO-K1 cells by beta galactosidase enzyme fragment complement based fluorescence assay				Bioorg Med Chem Lett 27: 5230-5234 (2017) Article DOI: 10.1016/j.bmcl.2017.10.037 BindingDB Entry DOI: 10.7270/Q21V5HJT
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM50192831 (CHEMBL3895104 | US10188627, Compound 8h) Show SMILES CC(CCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CCC(O)=O Show InChI InChI=1S/C26H29NO5/c1-19(9-14-25(28)29)15-17-32-24-7-4-3-6-22(24)18-27(2)26(30)21-12-10-20(11-13-21)23-8-5-16-31-23/h3-8,10-13,16,19H,9,14-15,17-18H2,1-2H3,(H,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Mitobridge, Inc. Curated by ChEMBL					Assay Description Activation of human PPARalpha LBD expressed in CHO-K1 cells by beta galactosidase enzyme fragment complement based fluorescence assay				Bioorg Med Chem Lett 27: 5230-5234 (2017) Article DOI: 10.1016/j.bmcl.2017.10.037 BindingDB Entry DOI: 10.7270/Q21V5HJT
					More data for this Ligand-Target Pair
PPAR delta protein (Rattus norvegicus (Rat))	BDBM50192831 (CHEMBL3895104 | US10188627, Compound 8h) Show SMILES CC(CCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CCC(O)=O Show InChI InChI=1S/C26H29NO5/c1-19(9-14-25(28)29)15-17-32-24-7-4-3-6-22(24)18-27(2)26(30)21-12-10-20(11-13-21)23-8-5-16-31-23/h3-8,10-13,16,19H,9,14-15,17-18H2,1-2H3,(H,28,29)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	40.2	n/a	n/a	n/a	n/a
Mitobridge, Inc.; Salk Institute for Biological Studies US Patent					Assay Description Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...				US Patent US10188627 (2019) BindingDB Entry DOI: 10.7270/Q2HX1FR6
					More data for this Ligand-Target Pair