BindingDB PrimarySearch

BDBM50192903 8R-hydroxylobel-9-ene::CHEMBL425617

SMILES: CN1[C@@H](C[C@@H](O)c2ccccc2)CCC[C@H]1\C=C\c1ccccc1

InChI Key: InChIKey=IKYXUFYHDWVXST-OWHMEISOSA-N

Data: 8 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50192903
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50192903 (8R-hydroxylobel-9-ene \| CHEMBL425617) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	44	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Inhibition of [3H]DA uptake at DAT in rat brain striatal synaptosomes by liquid scintillation spectrophotometry				Bioorg Med Chem 18: 640-9 (2010) Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2
University of Kentucky Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50192903 (8R-hydroxylobel-9-ene \| CHEMBL425617) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	44	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Inhibition of [3H]5-HT uptake at SERT in rat hippocampal synaptosomes				Bioorg Med Chem Lett 16: 5018-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.070 BindingDB Entry DOI: 10.7270/Q2513XTK
University of Kentucky Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50192903 (8R-hydroxylobel-9-ene \| CHEMBL425617) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	860	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Inhibition of [3H]5HT uptake at SERT in rat brain hippocampal synaptosomes by liquid scintillation spectrophotometry				Bioorg Med Chem 18: 640-9 (2010) Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2
University of Kentucky Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50192903 (8R-hydroxylobel-9-ene \| CHEMBL425617) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	860	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Inhibition of [3H]DA uptake at DAT in rat striatal synaptosomes				Bioorg Med Chem Lett 16: 5018-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.070 BindingDB Entry DOI: 10.7270/Q2513XTK
University of Kentucky Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor (Rattus norvegicus (Rat))	BDBM50192903 (8R-hydroxylobel-9-ene \| CHEMBL425617) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Inhibition of [3H]MLA binding to alpha7 nAChR in rat brain membrane				Bioorg Med Chem Lett 16: 5018-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.070 BindingDB Entry DOI: 10.7270/Q2513XTK
University of Kentucky Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit (Rattus norvegicus (Rat))	BDBM50192903 (8R-hydroxylobel-9-ene \| CHEMBL425617) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.19E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Inhibition of [3H]NIC binding to alpha4beta2 nAChR in rat brain membrane				Bioorg Med Chem Lett 16: 5018-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.070 BindingDB Entry DOI: 10.7270/Q2513XTK
University of Kentucky Curated by ChEMBL					More data for this Ligand-Target Pair
Synaptic vesicular amine transporter (Homo sapiens (Human))	BDBM50192903 (8R-hydroxylobel-9-ene \| CHEMBL425617) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5.16E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Binding affinity to VMAT2 receptor				Bioorg Med Chem 18: 640-9 (2010) Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2
University of Kentucky Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular monoamine transporter 2 (VMAT2) (Rattus norvegicus (Rat))	BDBM50192903 (8R-hydroxylobel-9-ene \| CHEMBL425617) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5.16E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membrane				Bioorg Med Chem Lett 16: 5018-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.070 BindingDB Entry DOI: 10.7270/Q2513XTK
University of Kentucky Curated by ChEMBL					More data for this Ligand-Target Pair