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SMILES: COc1ccc(cc1)-c1cc2c(NN3C(=O)C=C(C)C3=O)nc(nc2s1)-c1cccs1

InChI Key: InChIKey=FWEIYHPTBMPLPE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50193120   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor-type tyrosine-protein kinase FLT3 [K633Q]


(Homo sapiens (Human))		BDBM50193120
PNG
(CHEMBL3940328)
Show SMILES COc1ccc(cc1)-c1cc2c(NN3C(=O)C=C(C)C3=O)nc(nc2s1)-c1cccs1 |t:17|
Show InChI InChI=1S/C22H16N4O3S2/c1-12-10-18(27)26(22(12)28)25-19-15-11-17(13-5-7-14(29-2)8-6-13)31-21(15)24-20(23-19)16-4-3-9-30-16/h3-11H,1-2H3,(H,23,24,25)
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Article
PubMed
n/an/a 69n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FLT3 expressed in insect Sf21 cells preincubated for 15 mins followed by poly(Glu:Tyr) substrate addition for 30 mins...

Eur J Med Chem 120: 74-85 (2016)


Article DOI: 10.1016/j.ejmech.2016.05.022
BindingDB Entry DOI: 10.7270/Q2BG2QX3
More data for this
Ligand-Target Pair