BDBM50193122 CHEMBL3899727

SMILES: Cl.CC(C)CNCCOc1ccc(cc1)-c1sc2nc(nc(NN3C(=O)C=C(C)C3=O)c2c1C)-c1cccs1

InChI Key: InChIKey=OXWNJZSAKQEJRA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50193122   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50193122 (CHEMBL3899727) Show SMILES Cl.CC(C)CNCCOc1ccc(cc1)-c1sc2nc(nc(NN3C(=O)C=C(C)C3=O)c2c1C)-c1cccs1 |t:26| Show InChI InChI=1S/C28H29N5O3S2.ClH/c1-16(2)15-29-11-12-36-20-9-7-19(8-10-20)24-18(4)23-26(32-33-22(34)14-17(3)28(33)35)30-25(31-27(23)38-24)21-6-5-13-37-21;/h5-10,13-14,16,29H,11-12,15H2,1-4H3,(H,30,31,32);1H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of recombinant human FLT3 expressed in insect Sf21 cells preincubated for 15 mins followed by poly(Glu:Tyr) substrate addition for 30 mins...				Eur J Med Chem 120: 74-85 (2016) Article DOI: 10.1016/j.ejmech.2016.05.022 BindingDB Entry DOI: 10.7270/Q2BG2QX3
					More data for this Ligand-Target Pair