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BDBM50193410 CHEMBL536975::N-[(1S,2S)-2-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-4-trifluoromethoxy-benzamide hydrochloride

SMILES: C[C@@H](N[C@H]1CCCC[C@@H]1NC(=O)c1ccc(OC(F)(F)F)cc1)c1cccc2ccccc12

InChI Key: InChIKey=ZZLJUUCFYIBWJN-CQLNOVPUSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50193410   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Calcium sensing receptor


(Rattus norvegicus)		BDBM50193410
PNG
(CHEMBL536975 | N-[(1S,2S)-2-((R)-1-naphthalen-1-yl...)
Show SMILES C[C@@H](N[C@H]1CCCC[C@@H]1NC(=O)c1ccc(OC(F)(F)F)cc1)c1cccc2ccccc12
Show InChI InChI=1S/C26H27F3N2O2/c1-17(21-10-6-8-18-7-2-3-9-22(18)21)30-23-11-4-5-12-24(23)31-25(32)19-13-15-20(16-14-19)33-26(27,28)29/h2-3,6-10,13-17,23-24,30H,4-5,11-12H2,1H3,(H,31,32)/t17-,23+,24+/m1/s1
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n/an/a 250n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation

J Med Chem 49: 5119-28 (2006)


Article DOI: 10.1021/jm051233+
BindingDB Entry DOI: 10.7270/Q2DJ5GFC
More data for this
Ligand-Target Pair