BindingDB PrimarySearch

BDBM50193836 1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-phenylethanone::CHEMBL373821

SMILES: O=C(Cc1ccccc1)N1C[C@@H]2CCCN2C[C@H]1Cc1ccccc1

InChI Key: InChIKey=QXRXXIKAVZAGHZ-LEWJYISDSA-N

Data: 4 IC50 4 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50193836
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50193836 (1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazi...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of Arizona Curated by ChEMBL					Assay Description Activity at human MC4R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation				Bioorg Med Chem Lett 16: 5462-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.015 BindingDB Entry DOI: 10.7270/Q2XD11BD
University of Arizona Curated by ChEMBL					More data for this Ligand-Target Pair
Melanocortin receptor 3 (Homo sapiens (Human))	BDBM50193836 (1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazi...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of Arizona Curated by ChEMBL					Assay Description Activity at human MC3R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation				Bioorg Med Chem Lett 16: 5462-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.015 BindingDB Entry DOI: 10.7270/Q2XD11BD
University of Arizona Curated by ChEMBL					More data for this Ligand-Target Pair
Melanocortin receptor 5 (MC5R) (Homo sapiens (Human))	BDBM50193836 (1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazi...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of Arizona Curated by ChEMBL					Assay Description Activity at human MC5R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation				Bioorg Med Chem Lett 16: 5462-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.015 BindingDB Entry DOI: 10.7270/Q2XD11BD
University of Arizona Curated by ChEMBL					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50193836 (1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazi...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Arizona Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4R expressed in HEK293 cells				Bioorg Med Chem Lett 16: 5462-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.015 BindingDB Entry DOI: 10.7270/Q2XD11BD
University of Arizona Curated by ChEMBL					More data for this Ligand-Target Pair
Melanocortin receptor 3 (Homo sapiens (Human))	BDBM50193836 (1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazi...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
University of Arizona Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells				Bioorg Med Chem Lett 16: 5462-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.015 BindingDB Entry DOI: 10.7270/Q2XD11BD
University of Arizona Curated by ChEMBL					More data for this Ligand-Target Pair
Melanocortin receptor 5 (MC5R) (Homo sapiens (Human))	BDBM50193836 (1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazi...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Arizona Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells				Bioorg Med Chem Lett 16: 5462-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.015 BindingDB Entry DOI: 10.7270/Q2XD11BD
University of Arizona Curated by ChEMBL					More data for this Ligand-Target Pair
Melanocyte-stimulating hormone receptor (Homo sapiens (Human))	BDBM50193836 (1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazi...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
University of Arizona Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC1R expressed in HEK293 cells				Bioorg Med Chem Lett 16: 5462-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.015 BindingDB Entry DOI: 10.7270/Q2XD11BD
University of Arizona Curated by ChEMBL					More data for this Ligand-Target Pair
Melanocyte-stimulating hormone receptor (Homo sapiens (Human))	BDBM50193836 (1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazi...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of Arizona Curated by ChEMBL					Assay Description Activity at human MC1R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation				Bioorg Med Chem Lett 16: 5462-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.015 BindingDB Entry DOI: 10.7270/Q2XD11BD
University of Arizona Curated by ChEMBL					More data for this Ligand-Target Pair