BDBM50194110 (S)-N-(1-(7-(4-aminobutylamino)heptylamino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)butyramide::CHEMBL213645::Philanthotoxin-74
SMILES: CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCNCCCCN
InChI Key: InChIKey=YKCMCIWNASWOOP-QFIPXVFZSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GRIA1 (Homo sapiens (Human)) | BDBM50194110 ((S)-N-(1-(7-(4-aminobutylamino)heptylamino)-3-(4-h...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 168 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM glutamate-induced current | Bioorg Med Chem 18: 1381-7 (2010) Article DOI: 10.1016/j.bmc.2009.12.072 BindingDB Entry DOI: 10.7270/Q27W6CB2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Rattus norvegicus (Rat)) | BDBM50194110 ((S)-N-(1-(7-(4-aminobutylamino)heptylamino)-3-(4-h...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 168 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Danish University of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia... | J Med Chem 49: 5414-23 (2006) Article DOI: 10.1021/jm060606j BindingDB Entry DOI: 10.7270/Q24X57FS | |||||||||||
More data for this Ligand-Target Pair |