BDBM50194496 4-{3-[4-(4-fluoro-phenoxy)-cyclohexyl]-ureido}-benzoic acid::CHEMBL222160::cis-4-(3-(4-(4-fluorophenoxy)cyclohexyl)ureido)benzoic acid

SMILES: OC(=O)c1ccc(NC(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(F)cc2)cc1

InChI Key: InChIKey=GVMGPQHXRIFVME-MAEOIBBWSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50194496   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human))	BDBM50194496 (4-{3-[4-(4-fluoro-phenoxy)-cyclohexyl]-ureido}-ben...) Show SMILES OC(=O)c1ccc(NC(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(F)cc2)cc1 |wD:14.17,11.10,(2.04,-5.24,;3.32,-4.45,;3.28,-2.95,;4.64,-5.17,;5.96,-4.36,;7.31,-5.1,;7.35,-6.64,;8.71,-7.38,;10.01,-6.55,;10,-4.91,;11.31,-7.38,;12.61,-6.55,;13.91,-7.37,;15.2,-6.55,;15.2,-4.91,;13.91,-4.08,;12.61,-4.91,;16.51,-4.09,;17.81,-4.91,;17.8,-6.56,;19.1,-7.39,;20.41,-6.57,;21.71,-7.39,;20.4,-4.92,;19.11,-4.1,;6.04,-7.45,;4.69,-6.72,)| Show InChI InChI=1S/C20H21FN2O4/c21-14-3-9-17(10-4-14)27-18-11-7-16(8-12-18)23-20(26)22-15-5-1-13(2-6-15)19(24)25/h1-6,9-10,16,18H,7-8,11-12H2,(H,24,25)(H2,22,23,26)/t16-,18+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay				Bioorg Med Chem Lett 16: 5773-7 (2006) Article DOI: 10.1016/j.bmcl.2006.08.078 BindingDB Entry DOI: 10.7270/Q22Z155K
					More data for this Ligand-Target Pair
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human))	BDBM50194496 (4-{3-[4-(4-fluoro-phenoxy)-cyclohexyl]-ureido}-ben...) Show SMILES OC(=O)c1ccc(NC(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(F)cc2)cc1 |wD:14.17,11.10,(2.04,-5.24,;3.32,-4.45,;3.28,-2.95,;4.64,-5.17,;5.96,-4.36,;7.31,-5.1,;7.35,-6.64,;8.71,-7.38,;10.01,-6.55,;10,-4.91,;11.31,-7.38,;12.61,-6.55,;13.91,-7.37,;15.2,-6.55,;15.2,-4.91,;13.91,-4.08,;12.61,-4.91,;16.51,-4.09,;17.81,-4.91,;17.8,-6.56,;19.1,-7.39,;20.41,-6.57,;21.71,-7.39,;20.4,-4.92,;19.11,-4.1,;6.04,-7.45,;4.69,-6.72,)| Show InChI InChI=1S/C20H21FN2O4/c21-14-3-9-17(10-4-14)27-18-11-7-16(8-12-18)23-20(26)22-15-5-1-13(2-6-15)19(24)25/h1-6,9-10,16,18H,7-8,11-12H2,(H,24,25)(H2,22,23,26)/t16-,18+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	142	n/a	n/a	n/a	n/a	n/a	n/a
Colorado State University Curated by ChEMBL					Assay Description Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins...				Bioorg Med Chem 20: 3255-62 (2012) Article DOI: 10.1016/j.bmc.2012.03.058 BindingDB Entry DOI: 10.7270/Q28W3FB2
					More data for this Ligand-Target Pair
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human))	BDBM50194496 (4-{3-[4-(4-fluoro-phenoxy)-cyclohexyl]-ureido}-ben...) Show SMILES OC(=O)c1ccc(NC(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(F)cc2)cc1 |wD:14.17,11.10,(2.04,-5.24,;3.32,-4.45,;3.28,-2.95,;4.64,-5.17,;5.96,-4.36,;7.31,-5.1,;7.35,-6.64,;8.71,-7.38,;10.01,-6.55,;10,-4.91,;11.31,-7.38,;12.61,-6.55,;13.91,-7.37,;15.2,-6.55,;15.2,-4.91,;13.91,-4.08,;12.61,-4.91,;16.51,-4.09,;17.81,-4.91,;17.8,-6.56,;19.1,-7.39,;20.41,-6.57,;21.71,-7.39,;20.4,-4.92,;19.11,-4.1,;6.04,-7.45,;4.69,-6.72,)| Show InChI InChI=1S/C20H21FN2O4/c21-14-3-9-17(10-4-14)27-18-11-7-16(8-12-18)23-20(26)22-15-5-1-13(2-6-15)19(24)25/h1-6,9-10,16,18H,7-8,11-12H2,(H,24,25)(H2,22,23,26)/t16-,18+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
University of California-Davis Curated by ChEMBL					Assay Description Inhibition of human recombinant soluble epoxide hydrolase				J Med Chem 50: 3825-40 (2007) Article DOI: 10.1021/jm070270t BindingDB Entry DOI: 10.7270/Q2TQ62BW
					More data for this Ligand-Target Pair