BDBM50194890 CHEMBL374193::N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(3-(methylsulfonyl)phenyl)picolinamide

SMILES: CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(n2)-c2cccc(c2)S(C)(=O)=O)cc1

InChI Key: InChIKey=YMSORXXIQGLXBK-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50194890   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50194890 (CHEMBL374193 | N-(4-(methylsulfonyl)benzyl)-4-amin...) Show SMILES CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(n2)-c2cccc(c2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C22H20N4O5S2/c1-32(28,29)16-8-6-14(7-9-16)13-25-22(27)20-11-19(24)18(12-23)21(26-20)15-4-3-5-17(10-15)33(2,30)31/h3-11H,13H2,1-2H3,(H2,24,26)(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of JNK2 by ATF2 phosphorylation assay				Bioorg Med Chem Lett 16: 5723-30 (2006) Article DOI: 10.1016/j.bmcl.2006.08.097 BindingDB Entry DOI: 10.7270/Q28G8KBG
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50194890 (CHEMBL374193 | N-(4-(methylsulfonyl)benzyl)-4-amin...) Show SMILES CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(n2)-c2cccc(c2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C22H20N4O5S2/c1-32(28,29)16-8-6-14(7-9-16)13-25-22(27)20-11-19(24)18(12-23)21(26-20)15-4-3-5-17(10-15)33(2,30)31/h3-11H,13H2,1-2H3,(H2,24,26)(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	43.0	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of JNK1				Eur J Med Chem 43: 604-13 (2008) Article DOI: 10.1016/j.ejmech.2007.04.020 BindingDB Entry DOI: 10.7270/Q2T43V9Z
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50194890 (CHEMBL374193 | N-(4-(methylsulfonyl)benzyl)-4-amin...) Show SMILES CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(n2)-c2cccc(c2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C22H20N4O5S2/c1-32(28,29)16-8-6-14(7-9-16)13-25-22(27)20-11-19(24)18(12-23)21(26-20)15-4-3-5-17(10-15)33(2,30)31/h3-11H,13H2,1-2H3,(H2,24,26)(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of JNK1 by ATF2 phosphorylation assay				Bioorg Med Chem Lett 16: 5723-30 (2006) Article DOI: 10.1016/j.bmcl.2006.08.097 BindingDB Entry DOI: 10.7270/Q28G8KBG
					More data for this Ligand-Target Pair