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SMILES: Cc1nc(C)c(s1)-c1csc(Nc2ncccn2)n1

InChI Key: InChIKey=TYZBDOQASLMQPK-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50195052   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50195052
PNG
(CHEMBL3919377)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ncccn2)n1
Show InChI InChI=1S/C12H11N5S2/c1-7-10(19-8(2)15-7)9-6-18-12(16-9)17-11-13-4-3-5-14-11/h3-6H,1-2H3,(H,13,14,16,17)
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Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL...

Bioorg Med Chem Lett 26: 4930-4935 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5
More data for this
Ligand-Target Pair