BDBM50195221 CHEMBL3971734

SMILES: Cc1nc(C)c(s1)-c1csc(Nc2cc(ccn2)C#N)n1

InChI Key: InChIKey=XLWUFUYBUPYRLN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50195221   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (Homo sapiens (Human))	BDBM50195221 (CHEMBL3971734) Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2cc(ccn2)C#N)n1 Show InChI InChI=1S/C14H11N5S2/c1-8-13(21-9(2)17-8)11-7-20-14(18-11)19-12-5-10(6-15)3-4-16-12/h3-5,7H,1-2H3,(H,16,18,19)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi& Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL...				Bioorg Med Chem Lett 26: 4930-4935 (2016) Article DOI: 10.1016/j.bmcl.2016.09.013 BindingDB Entry DOI: 10.7270/Q2BC41H5
					More data for this Ligand-Target Pair