Found 5 hits for monomerid = 50195493 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)
(Rattus norvegicus (rat)) | BDBM50195493
(4-amino-3,5-dichloro-N-cyclopropyl-N-((1s,4s)-4-(1...)Show SMILES CN1CCN(CC1)C(=O)[C@@H]1CC[C@@H](CC1)N(C1CC1)C(=O)c1cc(Cl)c(N)c(Cl)c1 |wU:9.9,12.16,(13.22,-48.19,;11.89,-47.41,;10.55,-48.17,;9.23,-47.4,;9.24,-45.86,;10.57,-45.09,;11.9,-45.87,;7.91,-45.09,;6.57,-45.85,;7.92,-43.55,;9.25,-42.78,;9.26,-41.24,;7.92,-40.47,;6.59,-41.24,;6.59,-42.77,;7.92,-38.93,;6.59,-38.16,;5.82,-36.82,;5.05,-38.16,;9.26,-38.16,;9.26,-36.62,;10.59,-38.93,;11.92,-38.16,;13.25,-38.92,;14.59,-38.15,;13.26,-40.47,;14.6,-41.24,;11.92,-41.24,;11.92,-42.78,;10.59,-40.47,)| Show InChI InChI=1S/C22H30Cl2N4O2/c1-26-8-10-27(11-9-26)21(29)14-2-4-16(5-3-14)28(17-6-7-17)22(30)15-12-18(23)20(25)19(24)13-15/h12-14,16-17H,2-11,25H2,1H3/t14-,16+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of rat 11beta-HSD1 |
Bioorg Med Chem Lett 16: 6241-5 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.035 BindingDB Entry DOI: 10.7270/Q2B857R4 |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50195493
(4-amino-3,5-dichloro-N-cyclopropyl-N-((1s,4s)-4-(1...)Show SMILES CN1CCN(CC1)C(=O)[C@@H]1CC[C@@H](CC1)N(C1CC1)C(=O)c1cc(Cl)c(N)c(Cl)c1 |wU:9.9,12.16,(13.22,-48.19,;11.89,-47.41,;10.55,-48.17,;9.23,-47.4,;9.24,-45.86,;10.57,-45.09,;11.9,-45.87,;7.91,-45.09,;6.57,-45.85,;7.92,-43.55,;9.25,-42.78,;9.26,-41.24,;7.92,-40.47,;6.59,-41.24,;6.59,-42.77,;7.92,-38.93,;6.59,-38.16,;5.82,-36.82,;5.05,-38.16,;9.26,-38.16,;9.26,-36.62,;10.59,-38.93,;11.92,-38.16,;13.25,-38.92,;14.59,-38.15,;13.26,-40.47,;14.6,-41.24,;11.92,-41.24,;11.92,-42.78,;10.59,-40.47,)| Show InChI InChI=1S/C22H30Cl2N4O2/c1-26-8-10-27(11-9-26)21(29)14-2-4-16(5-3-14)28(17-6-7-17)22(30)15-12-18(23)20(25)19(24)13-15/h12-14,16-17H,2-11,25H2,1H3/t14-,16+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 560 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human 11beta-HSD1 expressed in Escherichia coli by SPA |
Bioorg Med Chem Lett 16: 6241-5 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.035 BindingDB Entry DOI: 10.7270/Q2B857R4 |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 2
(Homo sapiens (Human)) | BDBM50195493
(4-amino-3,5-dichloro-N-cyclopropyl-N-((1s,4s)-4-(1...)Show SMILES CN1CCN(CC1)C(=O)[C@@H]1CC[C@@H](CC1)N(C1CC1)C(=O)c1cc(Cl)c(N)c(Cl)c1 |wU:9.9,12.16,(13.22,-48.19,;11.89,-47.41,;10.55,-48.17,;9.23,-47.4,;9.24,-45.86,;10.57,-45.09,;11.9,-45.87,;7.91,-45.09,;6.57,-45.85,;7.92,-43.55,;9.25,-42.78,;9.26,-41.24,;7.92,-40.47,;6.59,-41.24,;6.59,-42.77,;7.92,-38.93,;6.59,-38.16,;5.82,-36.82,;5.05,-38.16,;9.26,-38.16,;9.26,-36.62,;10.59,-38.93,;11.92,-38.16,;13.25,-38.92,;14.59,-38.15,;13.26,-40.47,;14.6,-41.24,;11.92,-41.24,;11.92,-42.78,;10.59,-40.47,)| Show InChI InChI=1S/C22H30Cl2N4O2/c1-26-8-10-27(11-9-26)21(29)14-2-4-16(5-3-14)28(17-6-7-17)22(30)15-12-18(23)20(25)19(24)13-15/h12-14,16-17H,2-11,25H2,1H3/t14-,16+ | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human 11beta-HSD2 by SPA |
Bioorg Med Chem Lett 16: 6241-5 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.035 BindingDB Entry DOI: 10.7270/Q2B857R4 |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 2
(Rattus norvegicus) | BDBM50195493
(4-amino-3,5-dichloro-N-cyclopropyl-N-((1s,4s)-4-(1...)Show SMILES CN1CCN(CC1)C(=O)[C@@H]1CC[C@@H](CC1)N(C1CC1)C(=O)c1cc(Cl)c(N)c(Cl)c1 |wU:9.9,12.16,(13.22,-48.19,;11.89,-47.41,;10.55,-48.17,;9.23,-47.4,;9.24,-45.86,;10.57,-45.09,;11.9,-45.87,;7.91,-45.09,;6.57,-45.85,;7.92,-43.55,;9.25,-42.78,;9.26,-41.24,;7.92,-40.47,;6.59,-41.24,;6.59,-42.77,;7.92,-38.93,;6.59,-38.16,;5.82,-36.82,;5.05,-38.16,;9.26,-38.16,;9.26,-36.62,;10.59,-38.93,;11.92,-38.16,;13.25,-38.92,;14.59,-38.15,;13.26,-40.47,;14.6,-41.24,;11.92,-41.24,;11.92,-42.78,;10.59,-40.47,)| Show InChI InChI=1S/C22H30Cl2N4O2/c1-26-8-10-27(11-9-26)21(29)14-2-4-16(5-3-14)28(17-6-7-17)22(30)15-12-18(23)20(25)19(24)13-15/h12-14,16-17H,2-11,25H2,1H3/t14-,16+ | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of rat 11beta-HSD2 |
Bioorg Med Chem Lett 16: 6241-5 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.035 BindingDB Entry DOI: 10.7270/Q2B857R4 |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50195493
(4-amino-3,5-dichloro-N-cyclopropyl-N-((1s,4s)-4-(1...)Show SMILES CN1CCN(CC1)C(=O)[C@@H]1CC[C@@H](CC1)N(C1CC1)C(=O)c1cc(Cl)c(N)c(Cl)c1 |wU:9.9,12.16,(13.22,-48.19,;11.89,-47.41,;10.55,-48.17,;9.23,-47.4,;9.24,-45.86,;10.57,-45.09,;11.9,-45.87,;7.91,-45.09,;6.57,-45.85,;7.92,-43.55,;9.25,-42.78,;9.26,-41.24,;7.92,-40.47,;6.59,-41.24,;6.59,-42.77,;7.92,-38.93,;6.59,-38.16,;5.82,-36.82,;5.05,-38.16,;9.26,-38.16,;9.26,-36.62,;10.59,-38.93,;11.92,-38.16,;13.25,-38.92,;14.59,-38.15,;13.26,-40.47,;14.6,-41.24,;11.92,-41.24,;11.92,-42.78,;10.59,-40.47,)| Show InChI InChI=1S/C22H30Cl2N4O2/c1-26-8-10-27(11-9-26)21(29)14-2-4-16(5-3-14)28(17-6-7-17)22(30)15-12-18(23)20(25)19(24)13-15/h12-14,16-17H,2-11,25H2,1H3/t14-,16+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human 11beta-HSD1 expressed in HEK293 cells by fluorescence polarization immuno-assay |
Bioorg Med Chem Lett 16: 6241-5 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.035 BindingDB Entry DOI: 10.7270/Q2B857R4 |
More data for this Ligand-Target Pair | |