BDBM50195878 1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea::CHEMBL241681

SMILES: Nc1ncc(-c2ccccc2)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12

InChI Key: InChIKey=FCCZSKATTXDLOB-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50195878   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50195878 (1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phen...) Show SMILES Nc1ncc(-c2ccccc2)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H18F4N4O2/c28-21-11-8-17(27(29,30)31)12-22(21)35-26(36)34-18-9-6-16(7-10-18)20-14-37-24-19(13-33-25(32)23(20)24)15-4-2-1-3-5-15/h1-14H,(H2,32,33)(H2,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline K.K. Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-6XHis-VEGFR2 by HTRF method				Bioorg Med Chem Lett 17: 250-4 (2006) Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50195878 (1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phen...) Show SMILES Nc1ncc(-c2ccccc2)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H18F4N4O2/c28-21-11-8-17(27(29,30)31)12-22(21)35-26(36)34-18-9-6-16(7-10-18)20-14-37-24-19(13-33-25(32)23(20)24)15-4-2-1-3-5-15/h1-14H,(H2,32,33)(H2,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline K.K. Curated by ChEMBL					Assay Description Inhibition of human EphB4 by scintillation proximity method				Bioorg Med Chem Lett 17: 250-4 (2006) Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50195878 (1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phen...) Show SMILES Nc1ncc(-c2ccccc2)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H18F4N4O2/c28-21-11-8-17(27(29,30)31)12-22(21)35-26(36)34-18-9-6-16(7-10-18)20-14-37-24-19(13-33-25(32)23(20)24)15-4-2-1-3-5-15/h1-14H,(H2,32,33)(H2,34,35,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline K.K. Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-Tie2 by HTRF method				Bioorg Med Chem Lett 17: 250-4 (2006) Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5
					More data for this Ligand-Target Pair