BDBM50195960 (R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-yl)-2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetamide::CHEMBL221009::N-[(4R)-3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-inden]-5'-yl]-2-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)acetamide

SMILES: CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4ccccc4[nH]c3=O)cc2C1

InChI Key: InChIKey=CGVMXRNLZJBUJV-OAQYLSRUSA-N

Data: 2 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50195960   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50195960 ((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...) Show SMILES CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4ccccc4[nH]c3=O)cc2C1 |r| Show InChI InChI=1S/C21H19N5O4/c1-25-19(29)24-18(28)21(25)9-12-6-7-14(8-13(12)10-21)22-17(27)11-26-16-5-3-2-4-15(16)23-20(26)30/h2-8H,9-11H2,1H3,(H,22,27)(H,23,30)(H,24,28,29)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	38	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cells				Bioorg Med Chem Lett 18: 6122-5 (2008) Article DOI: 10.1016/j.bmcl.2008.10.019 BindingDB Entry DOI: 10.7270/Q24Q7TTF
					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50195960 ((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...) Show SMILES CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4ccccc4[nH]c3=O)cc2C1 |r| Show InChI InChI=1S/C21H19N5O4/c1-25-19(29)24-18(28)21(25)9-12-6-7-14(8-13(12)10-21)22-17(27)11-26-16-5-3-2-4-15(16)23-20(26)30/h2-8H,9-11H2,1H3,(H,22,27)(H,23,30)(H,24,28,29)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	43	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cells				Bioorg Med Chem Lett 16: 6165-9 (2006) Article DOI: 10.1016/j.bmcl.2006.09.045 BindingDB Entry DOI: 10.7270/Q2HT2NZQ
					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50195960 ((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...) Show SMILES CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4ccccc4[nH]c3=O)cc2C1 |r| Show InChI InChI=1S/C21H19N5O4/c1-25-19(29)24-18(28)21(25)9-12-6-7-14(8-13(12)10-21)22-17(27)11-26-16-5-3-2-4-15(16)23-20(26)30/h2-8H,9-11H2,1H3,(H,22,27)(H,23,30)(H,24,28,29)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of CGRP-induced cAMP production in E10 cells				Bioorg Med Chem Lett 16: 6165-9 (2006) Article DOI: 10.1016/j.bmcl.2006.09.045 BindingDB Entry DOI: 10.7270/Q2HT2NZQ
					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50195960 ((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...) Show SMILES CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4ccccc4[nH]c3=O)cc2C1 |r| Show InChI InChI=1S/C21H19N5O4/c1-25-19(29)24-18(28)21(25)9-12-6-7-14(8-13(12)10-21)22-17(27)11-26-16-5-3-2-4-15(16)23-20(26)30/h2-8H,9-11H2,1H3,(H,22,27)(H,23,30)(H,24,28,29)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production				Bioorg Med Chem Lett 18: 6122-5 (2008) Article DOI: 10.1016/j.bmcl.2008.10.019 BindingDB Entry DOI: 10.7270/Q24Q7TTF
					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50195960 ((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...) Show SMILES CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4ccccc4[nH]c3=O)cc2C1 |r| Show InChI InChI=1S/C21H19N5O4/c1-25-19(29)24-18(28)21(25)9-12-6-7-14(8-13(12)10-21)22-17(27)11-26-16-5-3-2-4-15(16)23-20(26)30/h2-8H,9-11H2,1H3,(H,22,27)(H,23,30)(H,24,28,29)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of...				Bioorg Med Chem Lett 18: 6122-5 (2008) Article DOI: 10.1016/j.bmcl.2008.10.019 BindingDB Entry DOI: 10.7270/Q24Q7TTF
					More data for this Ligand-Target Pair