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SMILES: Cc1ccc2n([C@H]3CC[C@H](O)CC3)c(NC(=O)c3cccc(c3)C(F)(F)F)nc2c1

InChI Key: InChIKey=BMZOMVWNQVOUHM-QAQDUYKDSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50196144   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50196144
PNG
(CHEMBL3946259)
Show SMILES Cc1ccc2n([C@H]3CC[C@H](O)CC3)c(NC(=O)c3cccc(c3)C(F)(F)F)nc2c1 |r,wU:6.5,wD:9.9,(4.39,-32.64,;5.72,-33.41,;5.72,-34.95,;7.05,-35.72,;8.39,-34.95,;9.86,-35.43,;10.35,-36.89,;11.85,-37.21,;12.32,-38.68,;11.29,-39.83,;11.76,-41.29,;9.78,-39.5,;9.31,-38.04,;10.77,-34.17,;12.31,-34.17,;13.08,-32.84,;12.31,-31.51,;14.62,-32.84,;15.38,-31.51,;16.92,-31.5,;17.7,-32.84,;16.93,-34.18,;15.39,-34.18,;17.7,-35.51,;16.93,-36.84,;19.24,-35.51,;18.46,-36.84,;9.86,-32.92,;8.39,-33.4,;7.05,-32.63,)|
Show InChI InChI=1S/C22H22F3N3O2/c1-13-5-10-19-18(11-13)26-21(28(19)16-6-8-17(29)9-7-16)27-20(30)14-3-2-4-15(12-14)22(23,24)25/h2-5,10-12,16-17,29H,6-9H2,1H3,(H,26,27,30)/t16-,17-
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Similars
Article
PubMed
n/an/a>1.18E+4n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of N-terminal 6x-HIS-tagged wild type human recombinant EGFR (696 to 1022 residues) expressed in Sf9 cells pre-incubated for 90 mins follo...

J Med Chem 59: 6671-89 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01985
BindingDB Entry DOI: 10.7270/Q2RF5X00
More data for this
Ligand-Target Pair