Found 4 hits for monomerid = 50196673 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Histone deacetylase 2
(Homo sapiens (Human)) | BDBM50196673
(CHEMBL3940720)Show SMILES CCOc1ccc(C[C@H]2CC[C@H](CC2)C(=O)NO)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 |r,wU:8.7,11.14,(15.87,-1.64,;15.87,-3.18,;17.21,-3.95,;17.21,-5.49,;15.87,-6.26,;15.88,-7.81,;17.22,-8.57,;17.23,-10.11,;18.57,-10.88,;19.88,-10.09,;21.22,-10.87,;21.23,-12.41,;19.89,-13.18,;18.56,-12.42,;22.55,-13.18,;22.55,-14.72,;23.89,-12.41,;25.22,-13.18,;18.55,-7.8,;18.54,-6.26,;19.87,-5.49,;21.2,-6.25,;22.53,-5.48,;23.99,-5.96,;24.47,-7.42,;25.97,-7.74,;24.89,-4.72,;23.99,-3.48,;24.47,-2.01,;22.53,-3.95,;21.2,-3.17,;21.2,-1.63,;19.87,-3.95,)| Show InChI InChI=1S/C24H31N5O4/c1-4-18-20-21(29(3)27-18)24(31)26-22(25-20)17-13-15(8-11-19(17)33-5-2)12-14-6-9-16(10-7-14)23(30)28-32/h8,11,13-14,16,32H,4-7,9-10,12H2,1-3H3,(H,28,30)(H,25,26,31)/t14-,16+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Navarra
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant human C-terminal His-tagged HDAC2 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC substrate ... |
J Med Chem 59: 8967-9004 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00908
BindingDB Entry DOI: 10.7270/Q2KP8448 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50196673
(CHEMBL3940720)Show SMILES CCOc1ccc(C[C@H]2CC[C@H](CC2)C(=O)NO)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 |r,wU:8.7,11.14,(15.87,-1.64,;15.87,-3.18,;17.21,-3.95,;17.21,-5.49,;15.87,-6.26,;15.88,-7.81,;17.22,-8.57,;17.23,-10.11,;18.57,-10.88,;19.88,-10.09,;21.22,-10.87,;21.23,-12.41,;19.89,-13.18,;18.56,-12.42,;22.55,-13.18,;22.55,-14.72,;23.89,-12.41,;25.22,-13.18,;18.55,-7.8,;18.54,-6.26,;19.87,-5.49,;21.2,-6.25,;22.53,-5.48,;23.99,-5.96,;24.47,-7.42,;25.97,-7.74,;24.89,-4.72,;23.99,-3.48,;24.47,-2.01,;22.53,-3.95,;21.2,-3.17,;21.2,-1.63,;19.87,-3.95,)| Show InChI InChI=1S/C24H31N5O4/c1-4-18-20-21(29(3)27-18)24(31)26-22(25-20)17-13-15(8-11-19(17)33-5-2)12-14-6-9-16(10-7-14)23(30)28-32/h8,11,13-14,16,32H,4-7,9-10,12H2,1-3H3,(H,28,30)(H,25,26,31)/t14-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Navarra
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant human N-terminal GST-tagged PDE5A1 expressed in baculovirus infected Sf9 cells using cGMP as substrate after 30... |
J Med Chem 59: 8967-9004 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00908
BindingDB Entry DOI: 10.7270/Q2KP8448 |
More data for this
Ligand-Target Pair | |
Cereblon/Histone deacetylase 6
(Homo sapiens (Human)) | BDBM50196673
(CHEMBL3940720)Show SMILES CCOc1ccc(C[C@H]2CC[C@H](CC2)C(=O)NO)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 |r,wU:8.7,11.14,(15.87,-1.64,;15.87,-3.18,;17.21,-3.95,;17.21,-5.49,;15.87,-6.26,;15.88,-7.81,;17.22,-8.57,;17.23,-10.11,;18.57,-10.88,;19.88,-10.09,;21.22,-10.87,;21.23,-12.41,;19.89,-13.18,;18.56,-12.42,;22.55,-13.18,;22.55,-14.72,;23.89,-12.41,;25.22,-13.18,;18.55,-7.8,;18.54,-6.26,;19.87,-5.49,;21.2,-6.25,;22.53,-5.48,;23.99,-5.96,;24.47,-7.42,;25.97,-7.74,;24.89,-4.72,;23.99,-3.48,;24.47,-2.01,;22.53,-3.95,;21.2,-3.17,;21.2,-1.63,;19.87,-3.95,)| Show InChI InChI=1S/C24H31N5O4/c1-4-18-20-21(29(3)27-18)24(31)26-22(25-20)17-13-15(8-11-19(17)33-5-2)12-14-6-9-16(10-7-14)23(30)28-32/h8,11,13-14,16,32H,4-7,9-10,12H2,1-3H3,(H,28,30)(H,25,26,31)/t14-,16+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Navarra
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant human N-terminal GST tagged HDAC6 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC substrate ... |
J Med Chem 59: 8967-9004 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00908
BindingDB Entry DOI: 10.7270/Q2KP8448 |
More data for this
Ligand-Target Pair | |
Histone deacetylase 1
(Homo sapiens (Human)) | BDBM50196673
(CHEMBL3940720)Show SMILES CCOc1ccc(C[C@H]2CC[C@H](CC2)C(=O)NO)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 |r,wU:8.7,11.14,(15.87,-1.64,;15.87,-3.18,;17.21,-3.95,;17.21,-5.49,;15.87,-6.26,;15.88,-7.81,;17.22,-8.57,;17.23,-10.11,;18.57,-10.88,;19.88,-10.09,;21.22,-10.87,;21.23,-12.41,;19.89,-13.18,;18.56,-12.42,;22.55,-13.18,;22.55,-14.72,;23.89,-12.41,;25.22,-13.18,;18.55,-7.8,;18.54,-6.26,;19.87,-5.49,;21.2,-6.25,;22.53,-5.48,;23.99,-5.96,;24.47,-7.42,;25.97,-7.74,;24.89,-4.72,;23.99,-3.48,;24.47,-2.01,;22.53,-3.95,;21.2,-3.17,;21.2,-1.63,;19.87,-3.95,)| Show InChI InChI=1S/C24H31N5O4/c1-4-18-20-21(29(3)27-18)24(31)26-22(25-20)17-13-15(8-11-19(17)33-5-2)12-14-6-9-16(10-7-14)23(30)28-32/h8,11,13-14,16,32H,4-7,9-10,12H2,1-3H3,(H,28,30)(H,25,26,31)/t14-,16+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 346 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Navarra
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant human C-terminal His/Flag-tagged HDAC1 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC subst... |
J Med Chem 59: 8967-9004 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00908
BindingDB Entry DOI: 10.7270/Q2KP8448 |
More data for this
Ligand-Target Pair | |
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