BDBM50196697 1-benzyl-3-(1H-indazol-5-yl)urea::CHEMBL225282::N-benzyl-N0-(1H-5-indazolyl)urea::US9409868, 12

SMILES: O=C(NCc1ccccc1)Nc1ccc2[nH]ncc2c1

InChI Key: InChIKey=CXBJSHXVWUZPRT-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50196697   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 1 (ROCK1) (Homo sapiens (Human))	BDBM50196697 (1-benzyl-3-(1H-indazol-5-yl)urea | CHEMBL225282 | ...) Show SMILES O=C(NCc1ccccc1)Nc1ccc2[nH]ncc2c1 Show InChI InChI=1S/C15H14N4O/c20-15(16-9-11-4-2-1-3-5-11)18-13-6-7-14-12(8-13)10-17-19-14/h1-8,10H,9H2,(H,17,19)(H2,16,18,20)	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	1.39E+4	n/a	n/a	n/a	n/a	7.5	25
H. Lee Moffin Cancer Center and Research Institute, Inc. US Patent					Assay Description A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...				US Patent US9409868 (2016) BindingDB Entry DOI: 10.7270/Q2X63KT0
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2) (Homo sapiens (Human))	BDBM50196697 (1-benzyl-3-(1H-indazol-5-yl)urea | CHEMBL225282 | ...) Show SMILES O=C(NCc1ccccc1)Nc1ccc2[nH]ncc2c1 Show InChI InChI=1S/C15H14N4O/c20-15(16-9-11-4-2-1-3-5-11)18-13-6-7-14-12(8-13)10-17-19-14/h1-8,10H,9H2,(H,17,19)(H2,16,18,20)	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	7.5	25
H. Lee Moffin Cancer Center and Research Institute, Inc. US Patent					Assay Description A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...				US Patent US9409868 (2016) BindingDB Entry DOI: 10.7270/Q2X63KT0
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50196697 (1-benzyl-3-(1H-indazol-5-yl)urea | CHEMBL225282 | ...) Show SMILES O=C(NCc1ccccc1)Nc1ccc2[nH]ncc2c1 Show InChI InChI=1S/C15H14N4O/c20-15(16-9-11-4-2-1-3-5-11)18-13-6-7-14-12(8-13)10-17-19-14/h1-8,10H,9H2,(H,17,19)(H2,16,18,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.39E+4	n/a	n/a	n/a	n/a	n/a	n/a
H. Lee Moffitt Cancer Center and Research Institute Curated by ChEMBL					Assay Description Inhibition of human His-puritin-tagged ROCK1 expressed in Sf9 cells after 1 hr by FRET-based enzyme-coupled assay				J Med Chem 55: 2474-8 (2012) Article DOI: 10.1021/jm201289r BindingDB Entry DOI: 10.7270/Q2MG7QH3
					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50196697 (1-benzyl-3-(1H-indazol-5-yl)urea | CHEMBL225282 | ...) Show SMILES O=C(NCc1ccccc1)Nc1ccc2[nH]ncc2c1 Show InChI InChI=1S/C15H14N4O/c20-15(16-9-11-4-2-1-3-5-11)18-13-6-7-14-12(8-13)10-17-19-14/h1-8,10H,9H2,(H,17,19)(H2,16,18,20)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Kirin Brewery Co. Ltd Curated by ChEMBL					Assay Description Inhibition of MCP1-induced cell migration in U937 cells expressing CCR2 by chemotaxis assay				Bioorg Med Chem 15: 350-64 (2006) Article DOI: 10.1016/j.bmc.2006.09.052 BindingDB Entry DOI: 10.7270/Q2T43TW5
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50196697 (1-benzyl-3-(1H-indazol-5-yl)urea | CHEMBL225282 | ...) Show SMILES O=C(NCc1ccccc1)Nc1ccc2[nH]ncc2c1 Show InChI InChI=1S/C15H14N4O/c20-15(16-9-11-4-2-1-3-5-11)18-13-6-7-14-12(8-13)10-17-19-14/h1-8,10H,9H2,(H,17,19)(H2,16,18,20)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
H. Lee Moffitt Cancer Center and Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 after 1 hr by FRET-based enzyme-coupled assay				J Med Chem 55: 2474-8 (2012) Article DOI: 10.1021/jm201289r BindingDB Entry DOI: 10.7270/Q2MG7QH3
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I) (Homo sapiens (Human))	BDBM50196697 (1-benzyl-3-(1H-indazol-5-yl)urea | CHEMBL225282 | ...) Show SMILES O=C(NCc1ccccc1)Nc1ccc2[nH]ncc2c1 Show InChI InChI=1S/C15H14N4O/c20-15(16-9-11-4-2-1-3-5-11)18-13-6-7-14-12(8-13)10-17-19-14/h1-8,10H,9H2,(H,17,19)(H2,16,18,20)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Kirin Brewery Co. Ltd Curated by ChEMBL					Assay Description Inhibition of Rho kinase				Bioorg Med Chem 15: 350-64 (2006) Article DOI: 10.1016/j.bmc.2006.09.052 BindingDB Entry DOI: 10.7270/Q2T43TW5
					More data for this Ligand-Target Pair