Found 4 hits for monomerid = 50196766 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Histone deacetylase 2
(Homo sapiens (Human)) | BDBM50196766
(CHEMBL3974954)Show SMILES CCOc1ccc(Oc2ccc(cc2)C(=O)NO)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 Show InChI InChI=1S/C23H23N5O5/c1-4-17-19-20(28(3)26-17)23(30)25-21(24-19)16-12-15(10-11-18(16)32-5-2)33-14-8-6-13(7-9-14)22(29)27-31/h6-12,31H,4-5H2,1-3H3,(H,27,29)(H,24,25,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Navarra
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant human C-terminal His-tagged HDAC2 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC substrate ... |
J Med Chem 59: 8967-9004 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00908
BindingDB Entry DOI: 10.7270/Q2KP8448 |
More data for this
Ligand-Target Pair | |
Histone deacetylase 1
(Homo sapiens (Human)) | BDBM50196766
(CHEMBL3974954)Show SMILES CCOc1ccc(Oc2ccc(cc2)C(=O)NO)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 Show InChI InChI=1S/C23H23N5O5/c1-4-17-19-20(28(3)26-17)23(30)25-21(24-19)16-12-15(10-11-18(16)32-5-2)33-14-8-6-13(7-9-14)22(29)27-31/h6-12,31H,4-5H2,1-3H3,(H,27,29)(H,24,25,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 566 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Navarra
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant human C-terminal His/Flag-tagged HDAC1 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC subst... |
J Med Chem 59: 8967-9004 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00908
BindingDB Entry DOI: 10.7270/Q2KP8448 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50196766
(CHEMBL3974954)Show SMILES CCOc1ccc(Oc2ccc(cc2)C(=O)NO)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 Show InChI InChI=1S/C23H23N5O5/c1-4-17-19-20(28(3)26-17)23(30)25-21(24-19)16-12-15(10-11-18(16)32-5-2)33-14-8-6-13(7-9-14)22(29)27-31/h6-12,31H,4-5H2,1-3H3,(H,27,29)(H,24,25,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Navarra
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant human N-terminal GST-tagged PDE5A1 expressed in baculovirus infected Sf9 cells using cGMP as substrate after 30... |
J Med Chem 59: 8967-9004 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00908
BindingDB Entry DOI: 10.7270/Q2KP8448 |
More data for this
Ligand-Target Pair | |
Cereblon/Histone deacetylase 6
(Homo sapiens (Human)) | BDBM50196766
(CHEMBL3974954)Show SMILES CCOc1ccc(Oc2ccc(cc2)C(=O)NO)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 Show InChI InChI=1S/C23H23N5O5/c1-4-17-19-20(28(3)26-17)23(30)25-21(24-19)16-12-15(10-11-18(16)32-5-2)33-14-8-6-13(7-9-14)22(29)27-31/h6-12,31H,4-5H2,1-3H3,(H,27,29)(H,24,25,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 196 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Navarra
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant human N-terminal GST tagged HDAC6 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC substrate ... |
J Med Chem 59: 8967-9004 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00908
BindingDB Entry DOI: 10.7270/Q2KP8448 |
More data for this
Ligand-Target Pair | |
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