BindingDB PrimarySearch

BDBM50197408 2-(3-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adamantan-2-yl)-propionamide::CHEMBL399191

SMILES: CC(C)(Oc1cccc(Cl)c1)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O

InChI Key: InChIKey=ZZXWSNKEDMSRRS-OQZFIPPTSA-N

Data: 2 KI 3 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50197408
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50197408 (2-(3-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adama...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human HSD1 assessed as interconversion of cortisone to cortisol				Bioorg Med Chem Lett 17: 527-32 (2007) Article DOI: 10.1016/j.bmcl.2006.10.008 BindingDB Entry DOI: 10.7270/Q2BZ65PP
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50197408 (2-(3-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adama...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse HSD1 assessed as interconversion of cortisone to cortisol				Bioorg Med Chem Lett 17: 527-32 (2007) Article DOI: 10.1016/j.bmcl.2006.10.008 BindingDB Entry DOI: 10.7270/Q2BZ65PP
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) (Mus musculus (mouse))	BDBM50197408 (2-(3-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adama...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse HSD2 assessed as interconversion of cortisone to cortisol				Bioorg Med Chem Lett 17: 527-32 (2007) Article DOI: 10.1016/j.bmcl.2006.10.008 BindingDB Entry DOI: 10.7270/Q2BZ65PP
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50197408 (2-(3-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adama...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human HSD1 expressed in HEK cells				Bioorg Med Chem Lett 17: 527-32 (2007) Article DOI: 10.1016/j.bmcl.2006.10.008 BindingDB Entry DOI: 10.7270/Q2BZ65PP
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 2 (Homo sapiens (Human))	BDBM50197408 (2-(3-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adama...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human HSD2 assessed as interconversion of cortisone to cortisol				Bioorg Med Chem Lett 17: 527-32 (2007) Article DOI: 10.1016/j.bmcl.2006.10.008 BindingDB Entry DOI: 10.7270/Q2BZ65PP
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair