BDBM50197524 CHEMBL3957061

SMILES: Cn1ccc(c1)-c1ccc2n(cnc2c1)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C)cc1

InChI Key: InChIKey=REQJIWOWTBYYLI-UHFFFAOYSA-N

Data: 2 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50197524   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50197524 (CHEMBL3957061) Show SMILES Cn1ccc(c1)-c1ccc2n(cnc2c1)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C)cc1 Show InChI InChI=1S/C27H27N5O2/c1-27(2,3)24-15-25(30-34-24)29-26(33)13-18-5-8-21(9-6-18)32-17-28-22-14-19(7-10-23(22)32)20-11-12-31(4)16-20/h5-12,14-17H,13H2,1-4H3,(H,29,30,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals Curated by ChEMBL					Assay Description Binding affinity to of human partial length VGFR2 expressed in mammalian system by active site-directed competition binding assay				J Med Chem 60: 89-99 (2017) Article DOI: 10.1021/acs.jmedchem.6b01123 BindingDB Entry DOI: 10.7270/Q2R78H5B
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50197524 (CHEMBL3957061) Show SMILES Cn1ccc(c1)-c1ccc2n(cnc2c1)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C)cc1 Show InChI InChI=1S/C27H27N5O2/c1-27(2,3)24-15-25(30-34-24)29-26(33)13-18-5-8-21(9-6-18)32-17-28-22-14-19(7-10-23(22)32)20-11-12-31(4)16-20/h5-12,14-17H,13H2,1-4H3,(H,29,30,33)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals Curated by ChEMBL					Assay Description Binding affinity to of human partial length RET expressed in bacterial system by active site-directed competition binding assay				J Med Chem 60: 89-99 (2017) Article DOI: 10.1021/acs.jmedchem.6b01123 BindingDB Entry DOI: 10.7270/Q2R78H5B
					More data for this Ligand-Target Pair