BindingDB PrimarySearch

BDBM50197834 2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-one::CHEMBL388956::SCH-546909::aristolactam AIIIa::aristololactam A IIIa

SMILES: COc1c(O)cc2C(=O)Nc3cc4ccc(O)cc4c1c23

InChI Key: InChIKey=PFXGXKFPTAJYHV-UHFFFAOYSA-N

Data: 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50197834
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Aurora kinase B (Homo sapiens (Human))	BDBM50197834 (2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-on...) Show SMILES COc1c(O)cc2C(=O)Nc3cc4ccc(O)cc4c1c23 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of Aurora 2 kinase				Bioorg Med Chem Lett 20: 1344-6 (2010) Article DOI: 10.1016/j.bmcl.2010.01.018 BindingDB Entry DOI: 10.7270/Q2BZ664X
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM50197834 (2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-on...) Show SMILES COc1c(O)cc2C(=O)Nc3cc4ccc(O)cc4c1c23 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of CDC2				Bioorg Med Chem Lett 20: 1384-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.007 BindingDB Entry DOI: 10.7270/Q2QF8TTB
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50197834 (2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-on...) Show SMILES COc1c(O)cc2C(=O)Nc3cc4ccc(O)cc4c1c23 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 20: 1344-6 (2010) Article DOI: 10.1016/j.bmcl.2010.01.018 BindingDB Entry DOI: 10.7270/Q2BZ664X
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50197834 (2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-on...) Show SMILES COc1c(O)cc2C(=O)Nc3cc4ccc(O)cc4c1c23 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of AUR2				Bioorg Med Chem Lett 20: 1384-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.007 BindingDB Entry DOI: 10.7270/Q2QF8TTB
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM50197834 (2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-on...) Show SMILES COc1c(O)cc2C(=O)Nc3cc4ccc(O)cc4c1c23 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.42E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK4				Bioorg Med Chem Lett 20: 1344-6 (2010) Article DOI: 10.1016/j.bmcl.2010.01.018 BindingDB Entry DOI: 10.7270/Q2BZ664X
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50197834 (2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-on...) Show SMILES COc1c(O)cc2C(=O)Nc3cc4ccc(O)cc4c1c23 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 20: 1384-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.007 BindingDB Entry DOI: 10.7270/Q2QF8TTB
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM50197834 (2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-on...) Show SMILES COc1c(O)cc2C(=O)Nc3cc4ccc(O)cc4c1c23 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK4				Bioorg Med Chem Lett 20: 1384-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.007 BindingDB Entry DOI: 10.7270/Q2QF8TTB
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM50197834 (2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-on...) Show SMILES COc1c(O)cc2C(=O)Nc3cc4ccc(O)cc4c1c23 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	214	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of CDC2				Bioorg Med Chem Lett 20: 1344-6 (2010) Article DOI: 10.1016/j.bmcl.2010.01.018 BindingDB Entry DOI: 10.7270/Q2BZ664X
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair