BDBM50198139 CHEMBL397717::N-{4-[1-({[3,5-bis(trifluoromethyl)phenyl]methyl}carbamoyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]propyl]-1,3-thiazol-2-yl}bicyclo[4.2.0]octa-1(6),2,4-triene-7-carboxamide
SMILES: C[C@H]1CN(CCC(C(=O)NCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c2csc(NC(=O)C3Cc4ccccc34)n2)CC[C@]11C=Cc2ccccc12
InChI Key: InChIKey=RLNPOKFCWGHIDM-NRUNXBEZSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50198139 (CHEMBL397717 | N-{4-[1-({[3,5-bis(trifluoromethyl)...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of [125I]MCP1 from human CCR2 expressed in monocytes | Bioorg Med Chem Lett 17: 309-14 (2007) Article DOI: 10.1016/j.bmcl.2006.10.059 BindingDB Entry DOI: 10.7270/Q25B0247 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Mus musculus) | BDBM50198139 (CHEMBL397717 | N-{4-[1-({[3,5-bis(trifluoromethyl)...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 111 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of [125I]MCP1 from mouse CCR2 expressed in monocytes | Bioorg Med Chem Lett 17: 309-14 (2007) Article DOI: 10.1016/j.bmcl.2006.10.059 BindingDB Entry DOI: 10.7270/Q25B0247 | |||||||||||
More data for this Ligand-Target Pair |