BDBM50198707 (2E)-(20S)-1alpha,25-dihydroxy-2-[2''-(fluoroethylidene)]-19-norvitamin D3::(2Z)-(20S)-1alpha,25-dihydroxy-2-[2''''-(fluoroethylidene)]-19-norvitamin D3::CHEMBL226380::CHEMBL388138
SMILES: C[C@@H](CCCC(C)(C)O)C1CCC2\C(CCCC12C)=C\C=C1C[C@@H](O)C(=CCF)[C@H](O)C1
InChI Key: InChIKey=NPQPAYRGQQTLEO-BBNBVWBZSA-N
Data: 2 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vitamin D3 receptor (Homo sapiens (Human)) | BDBM50198707 ((2E)-(20S)-1alpha,25-dihydroxy-2-[2''-(fluoroethyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a |
Tokyo Medical and Dental University Curated by ChEMBL | Assay Description Inhibition of human VDR induced-transcriptional transactivation of luciferase reporter gene in COS7 cells after 24 hrs | Bioorg Med Chem 15: 1475-82 (2007) Article DOI: 10.1016/j.bmc.2006.10.069 BindingDB Entry DOI: 10.7270/Q2TT4QK5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vitamin D3 receptor (Homo sapiens (Human)) | BDBM50198707 ((2E)-(20S)-1alpha,25-dihydroxy-2-[2''-(fluoroethyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a |
Tokyo Medical and Dental University Curated by ChEMBL | Assay Description Inhibition of human VDR induced-transcriptional transactivation of luciferase reporter gene in COS7 cells after 24 hrs | Bioorg Med Chem 15: 1475-82 (2007) Article DOI: 10.1016/j.bmc.2006.10.069 BindingDB Entry DOI: 10.7270/Q2TT4QK5 | |||||||||||
More data for this Ligand-Target Pair |