BDBM50198817 4-(7-(2,6-dimethylphenyl)-5-methylbenzo[e][1,2,4]triazin-3-ylamino)-N-(2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide::CHEMBL231218::US8481536, 404::US8481536, 586
SMILES: Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(cc3)S(=O)(=O)NCCN3CCCC3)nnc2c1
InChI Key: InChIKey=DYHVAHJSHIYCLL-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM50198817 (4-(7-(2,6-dimethylphenyl)-5-methylbenzo[e][1,2,4]t...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | 25 |
TargeGen, Inc. US Patent | Assay Description Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp. | US Patent US8481536 (2013) BindingDB Entry DOI: 10.7270/Q2GB22PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Yes (Homo sapiens (Human)) | BDBM50198817 (4-(7-(2,6-dimethylphenyl)-5-methylbenzo[e][1,2,4]t...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | 25 |
TargeGen, Inc. US Patent | Assay Description Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp. | US Patent US8481536 (2013) BindingDB Entry DOI: 10.7270/Q2GB22PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM50198817 (4-(7-(2,6-dimethylphenyl)-5-methylbenzo[e][1,2,4]t...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TargeGen, Inc. Curated by ChEMBL | Assay Description Inhibition of Src | Bioorg Med Chem Lett 17: 602-8 (2007) Article DOI: 10.1016/j.bmcl.2006.11.006 BindingDB Entry DOI: 10.7270/Q29024MW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-B receptor 4 (Homo sapiens (Human)) | BDBM50198817 (4-(7-(2,6-dimethylphenyl)-5-methylbenzo[e][1,2,4]t...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 73.7 | n/a | n/a | n/a | n/a | n/a | 37 |
TargeGen, Inc. US Patent | Assay Description Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp. | US Patent US8481536 (2013) BindingDB Entry DOI: 10.7270/Q2GB22PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM50198817 (4-(7-(2,6-dimethylphenyl)-5-methylbenzo[e][1,2,4]t...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TargeGen, Inc. US Patent | Assay Description Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp. | US Patent US8481536 (2013) BindingDB Entry DOI: 10.7270/Q2GB22PZ | |||||||||||
More data for this Ligand-Target Pair |