BDBM50199423 CHEMBL3983476

SMILES: COc1nn2cc(nc2s1)-c1ccc(Cl)cc1

InChI Key: InChIKey=UKCLNFBWHOFDDT-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50199423   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proteinase-activated receptor 4 (PAR4) (Homo sapiens (Human))	BDBM50199423 (CHEMBL3983476) Show SMILES COc1nn2cc(nc2s1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-2-4-8(12)5-3-7/h2-6H,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	286	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced P-selectin activation				Bioorg Med Chem Lett 26: 5481-5486 (2016) Article DOI: 10.1016/j.bmcl.2016.10.020 BindingDB Entry DOI: 10.7270/Q2P55QGD
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4) (Homo sapiens (Human))	BDBM50199423 (CHEMBL3983476) Show SMILES COc1nn2cc(nc2s1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-2-4-8(12)5-3-7/h2-6H,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...				Bioorg Med Chem Lett 26: 5481-5486 (2016) Article DOI: 10.1016/j.bmcl.2016.10.020 BindingDB Entry DOI: 10.7270/Q2P55QGD
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4) (Homo sapiens (Human))	BDBM50199423 (CHEMBL3983476) Show SMILES COc1nn2cc(nc2s1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-2-4-8(12)5-3-7/h2-6H,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	617	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...				Bioorg Med Chem Lett 26: 5481-5486 (2016) Article DOI: 10.1016/j.bmcl.2016.10.020 BindingDB Entry DOI: 10.7270/Q2P55QGD
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4) (Homo sapiens (Human))	BDBM50199423 (CHEMBL3983476) Show SMILES COc1nn2cc(nc2s1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-2-4-8(12)5-3-7/h2-6H,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	621	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced P-selectin activation				Bioorg Med Chem Lett 26: 5481-5486 (2016) Article DOI: 10.1016/j.bmcl.2016.10.020 BindingDB Entry DOI: 10.7270/Q2P55QGD
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4) (Homo sapiens (Human))	BDBM50199423 (CHEMBL3983476) Show SMILES COc1nn2cc(nc2s1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-2-4-8(12)5-3-7/h2-6H,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	621	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...				Bioorg Med Chem Lett 26: 5481-5486 (2016) Article DOI: 10.1016/j.bmcl.2016.10.020 BindingDB Entry DOI: 10.7270/Q2P55QGD
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4) (Homo sapiens (Human))	BDBM50199423 (CHEMBL3983476) Show SMILES COc1nn2cc(nc2s1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-2-4-8(12)5-3-7/h2-6H,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...				Bioorg Med Chem Lett 26: 5481-5486 (2016) Article DOI: 10.1016/j.bmcl.2016.10.020 BindingDB Entry DOI: 10.7270/Q2P55QGD
					More data for this Ligand-Target Pair