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SMILES: Fc1ccc2C(=O)N(Cc3cc(Cl)ccc3NC(=O)c3ccccn3)C(=O)c2c1

InChI Key: InChIKey=YQBPEFYDKGHACA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50202140   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50202140
PNG
(CHEMBL395388 | N-(4-chloro-2-((5-fluoro-1,3-dioxoi...)
Show SMILES Fc1ccc2C(=O)N(Cc3cc(Cl)ccc3NC(=O)c3ccccn3)C(=O)c2c1
Show InChI InChI=1S/C21H13ClFN3O3/c22-13-4-7-17(25-19(27)18-3-1-2-8-24-18)12(9-13)11-26-20(28)15-6-5-14(23)10-16(15)21(26)29/h1-10H,11H2,(H,25,27)
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Article
PubMed
n/an/an/an/a 330n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assay

Bioorg Med Chem Lett 17: 1386-91 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.081
BindingDB Entry DOI: 10.7270/Q22V2GXH
More data for this
Ligand-Target Pair