BDBM50202476 CHEMBL3945688

SMILES: COC(=O)COc1ccc2n(Cc3ccccc3C(F)(F)F)c(nc2c1)C(C)c1ccc(CC(C)C)cc1

InChI Key: InChIKey=UMPIPJNQFPGAIU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50202476   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM50202476 (CHEMBL3945688) Show SMILES COC(=O)COc1ccc2n(Cc3ccccc3C(F)(F)F)c(nc2c1)C(C)c1ccc(CC(C)C)cc1 Show InChI InChI=1S/C30H31F3N2O3/c1-19(2)15-21-9-11-22(12-10-21)20(3)29-34-26-16-24(38-18-28(36)37-4)13-14-27(26)35(29)17-23-7-5-6-8-25(23)30(31,32)33/h5-14,16,19-20H,15,17-18H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Gazi University Curated by ChEMBL					Assay Description Inhibition of FLAP in human neutrophils assessed as suppression of A23187-stimulated 5-LO product formation using arachidonic acid as substrate prein...				Eur J Med Chem 122: 510-519 (2016) Article DOI: 10.1016/j.ejmech.2016.07.004 BindingDB Entry DOI: 10.7270/Q2H41TCW
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