BDBM50202760 4-(3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)isoquinoline::CHEMBL391437

SMILES: c1ccc2[nH]c(nc2c1)-c1n[nH]c2ncc(cc12)-c1cncc2ccccc12

InChI Key: InChIKey=UBDAMLJKQGPQFB-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50202760   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50202760 (4-(3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]...) Show SMILES c1ccc2[nH]c(nc2c1)-c1n[nH]c2ncc(cc12)-c1cncc2ccccc12 Show InChI InChI=1S/C22H14N6/c1-2-6-15-13(5-1)10-23-12-17(15)14-9-16-20(27-28-21(16)24-11-14)22-25-18-7-3-4-8-19(18)26-22/h1-12H,(H,25,26)(H,24,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development L. L. C. Curated by ChEMBL					Assay Description Inhibition of VEGFR2				Bioorg Med Chem Lett 17: 1243-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.031 BindingDB Entry DOI: 10.7270/Q20Z72Z9
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50202760 (4-(3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]...) Show SMILES c1ccc2[nH]c(nc2c1)-c1n[nH]c2ncc(cc12)-c1cncc2ccccc12 Show InChI InChI=1S/C22H14N6/c1-2-6-15-13(5-1)10-23-12-17(15)14-9-16-20(27-28-21(16)24-11-14)22-25-18-7-3-4-8-19(18)26-22/h1-12H,(H,25,26)(H,24,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development L.L.C. Curated by ChEMBL					Assay Description Inhibition of VEGFR2				Bioorg Med Chem Lett 17: 4297-302 (2007) Article DOI: 10.1016/j.bmcl.2007.05.029 BindingDB Entry DOI: 10.7270/Q20C4VGJ
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM50202760 (4-(3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]...) Show SMILES c1ccc2[nH]c(nc2c1)-c1n[nH]c2ncc(cc12)-c1cncc2ccccc12 Show InChI InChI=1S/C22H14N6/c1-2-6-15-13(5-1)10-23-12-17(15)14-9-16-20(27-28-21(16)24-11-14)22-25-18-7-3-4-8-19(18)26-22/h1-12H,(H,25,26)(H,24,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development L.L.C. Curated by ChEMBL					Assay Description Inhibition of CDK1				Bioorg Med Chem Lett 17: 4297-302 (2007) Article DOI: 10.1016/j.bmcl.2007.05.029 BindingDB Entry DOI: 10.7270/Q20C4VGJ
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50202760 (4-(3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]...) Show SMILES c1ccc2[nH]c(nc2c1)-c1n[nH]c2ncc(cc12)-c1cncc2ccccc12 Show InChI InChI=1S/C22H14N6/c1-2-6-15-13(5-1)10-23-12-17(15)14-9-16-20(27-28-21(16)24-11-14)22-25-18-7-3-4-8-19(18)26-22/h1-12H,(H,25,26)(H,24,27,28)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development L.L.C. Curated by ChEMBL					Assay Description Inhibition of HER2				Bioorg Med Chem Lett 17: 4297-302 (2007) Article DOI: 10.1016/j.bmcl.2007.05.029 BindingDB Entry DOI: 10.7270/Q20C4VGJ
					More data for this Ligand-Target Pair