BindingDB PrimarySearch

BDBM50203985 (E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)-2-propen-1-one (18)::2,2',4,4'-tetrahydroxychalcone::2,4,2',4'-tetrahydroxychalcone::CHEMBL394855

SMILES: Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)c(O)c1

InChI Key: InChIKey=ZWTDXYUDJYDHJR-QHHAFSJGSA-N

Data: 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50203985
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM50203985 ((E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)c(O)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	4.5	37
Shanghai Institute of Materia Medica, Chinese Academy of Sciences					Assay Description The assay based on fluorescenceresonance energy transfer was carried out with BACE1 enzyme at pH 4.5 with a substrate, H-Lys(DABSYL)-SEVNLDAEFR-Gin-(...				J Enzyme Inhib Med Chem 26: 643-8 (2011) Article DOI: 10.3109/14756366.2010.543420 BindingDB Entry DOI: 10.7270/Q2DR2TCJ
					More data for this Ligand-Target Pair
Tyrosinase (Agaricus bisporus (Common mushroom))	BDBM50203985 ((E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)c(O)c1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hokkaido University Curated by ChEMBL					Assay Description Inhibition of mushroom tyrosinase				Bioorg Med Chem 15: 2396-402 (2007) Article DOI: 10.1016/j.bmc.2007.01.017 BindingDB Entry DOI: 10.7270/Q2R78DWH
Hokkaido University Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50203985 ((E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)c(O)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Rattus norvegicus (rat) lens aldose reductase				Citation and Details Article DOI: 10.1007/s00044-012-0367-5 BindingDB Entry DOI: 10.7270/Q2XP77VN
TBA					More data for this Ligand-Target Pair
Tyrosinase (Mus musculus (Mouse))	BDBM50203985 ((E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)c(O)c1 Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Inhibition of tyrosinase in mouse B16 cells assessed as reduction in melanin synthesis after 1 hr				J Med Chem 61: 7395-7418 (2018) Article DOI: 10.1021/acs.jmedchem.7b00967
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM50203985 ((E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)c(O)c1 Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Inhibition of tyrosinase (unknown origin)				J Med Chem 61: 7395-7418 (2018) Article DOI: 10.1021/acs.jmedchem.7b00967
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosinase (Mus musculus (Mouse))	BDBM50203985 ((E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)c(O)c1 Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Inhibition of tyrosinase in mouse B16 cells assessed as reduction in melanin synthesis after 1 hr				J Med Chem 61: 7395-7418 (2018) Article DOI: 10.1021/acs.jmedchem.7b00967
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM50203985 ((E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)c(O)c1 Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Inhibition of tyrosinase (unknown origin)				J Med Chem 61: 7395-7418 (2018) Article DOI: 10.1021/acs.jmedchem.7b00967
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosinase (Agaricus bisporus (Common mushroom))	BDBM50203985 ((E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)c(O)c1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of mushroom tyrosinase assessed as reduction in diphenolase activity using L-DOPA substrate pre-incubated for 20 mins at 30 degC				Bioorg Med Chem 21: 2156-62 (2013) Article DOI: 10.1016/j.bmc.2012.12.054 BindingDB Entry DOI: 10.7270/Q28P63FB
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair