BDBM50204763 1-phenyl-8-pyridin-3-ylmethyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL240896

SMILES: O=C1NCN(c2ccccc2)C11CCN(Cc2cccnc2)CC1

InChI Key: InChIKey=PJAYESDXFUNVMS-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50204763   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM50204763 (1-phenyl-8-pyridin-3-ylmethyl-1,3,8-triaza-spiro[4...) Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2cccnc2)CC1 Show InChI InChI=1S/C19H22N4O/c24-18-19(23(15-21-18)17-6-2-1-3-7-17)8-11-22(12-9-19)14-16-5-4-10-20-13-16/h1-7,10,13H,8-9,11-12,14-15H2,(H,21,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	133	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane				Bioorg Med Chem Lett 17: 2281-4 (2007) Article DOI: 10.1016/j.bmcl.2007.01.069 BindingDB Entry DOI: 10.7270/Q2T43SRZ
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50204763 (1-phenyl-8-pyridin-3-ylmethyl-1,3,8-triaza-spiro[4...) Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2cccnc2)CC1 Show InChI InChI=1S/C19H22N4O/c24-18-19(23(15-21-18)17-6-2-1-3-7-17)8-11-22(12-9-19)14-16-5-4-10-20-13-16/h1-7,10,13H,8-9,11-12,14-15H2,(H,21,24)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	233	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane				Bioorg Med Chem Lett 17: 2281-4 (2007) Article DOI: 10.1016/j.bmcl.2007.01.069 BindingDB Entry DOI: 10.7270/Q2T43SRZ
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50204763 (1-phenyl-8-pyridin-3-ylmethyl-1,3,8-triaza-spiro[4...) Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2cccnc2)CC1 Show InChI InChI=1S/C19H22N4O/c24-18-19(23(15-21-18)17-6-2-1-3-7-17)8-11-22(12-9-19)14-16-5-4-10-20-13-16/h1-7,10,13H,8-9,11-12,14-15H2,(H,21,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	252	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane				Bioorg Med Chem Lett 17: 2281-4 (2007) Article DOI: 10.1016/j.bmcl.2007.01.069 BindingDB Entry DOI: 10.7270/Q2T43SRZ
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM50204763 (1-phenyl-8-pyridin-3-ylmethyl-1,3,8-triaza-spiro[4...) Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2cccnc2)CC1 Show InChI InChI=1S/C19H22N4O/c24-18-19(23(15-21-18)17-6-2-1-3-7-17)8-11-22(12-9-19)14-16-5-4-10-20-13-16/h1-7,10,13H,8-9,11-12,14-15H2,(H,21,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.79E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane				Bioorg Med Chem Lett 17: 2281-4 (2007) Article DOI: 10.1016/j.bmcl.2007.01.069 BindingDB Entry DOI: 10.7270/Q2T43SRZ
					More data for this Ligand-Target Pair