BDBM50205262 CHEMBL3929484

SMILES: ONC(=O)CCCCCn1cc(nn1)-c1ccc2ncnc(Nc3cccc(Cl)c3F)c2c1

InChI Key: InChIKey=YBLBBOHIJOJAPV-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50205262   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50205262 (CHEMBL3929484) Show SMILES ONC(=O)CCCCCn1cc(nn1)-c1ccc2ncnc(Nc3cccc(Cl)c3F)c2c1 Show InChI InChI=1S/C22H21ClFN7O2/c23-16-5-4-6-18(21(16)24)27-22-15-11-14(8-9-17(15)25-13-26-22)19-12-31(30-28-19)10-3-1-2-7-20(32)29-33/h4-6,8-9,11-13,33H,1-3,7,10H2,(H,29,32)(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Tsinghua University Curated by ChEMBL					Assay Description Inhibition of HDAC6 (unknown origin) using acetylated peptide substrate preincubated for 15 mins followed by substrate addition measured after 60 min...				Bioorg Med Chem 25: 27-37 (2017) Article DOI: 10.1016/j.bmc.2016.10.006 BindingDB Entry DOI: 10.7270/Q22N548X
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50205262 (CHEMBL3929484) Show SMILES ONC(=O)CCCCCn1cc(nn1)-c1ccc2ncnc(Nc3cccc(Cl)c3F)c2c1 Show InChI InChI=1S/C22H21ClFN7O2/c23-16-5-4-6-18(21(16)24)27-22-15-11-14(8-9-17(15)25-13-26-22)19-12-31(30-28-19)10-3-1-2-7-20(32)29-33/h4-6,8-9,11-13,33H,1-3,7,10H2,(H,29,32)(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	n/a
Tsinghua University Curated by ChEMBL					Assay Description Inhibition of wild-type EGFR (unknown origin) assessed as remaining ATP level measured after 15 mins by luminescence analysis				Bioorg Med Chem 25: 27-37 (2017) Article DOI: 10.1016/j.bmc.2016.10.006 BindingDB Entry DOI: 10.7270/Q22N548X
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50205262 (CHEMBL3929484) Show SMILES ONC(=O)CCCCCn1cc(nn1)-c1ccc2ncnc(Nc3cccc(Cl)c3F)c2c1 Show InChI InChI=1S/C22H21ClFN7O2/c23-16-5-4-6-18(21(16)24)27-22-15-11-14(8-9-17(15)25-13-26-22)19-12-31(30-28-19)10-3-1-2-7-20(32)29-33/h4-6,8-9,11-13,33H,1-3,7,10H2,(H,29,32)(H,25,26,27)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	386	n/a	n/a	n/a	n/a	n/a	n/a
Tsinghua University Curated by ChEMBL					Assay Description Inhibition of HER2 (unknown origin) assessed as remaining ATP level measured after 15 mins by luminescence analysis				Bioorg Med Chem 25: 27-37 (2017) Article DOI: 10.1016/j.bmc.2016.10.006 BindingDB Entry DOI: 10.7270/Q22N548X
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50205262 (CHEMBL3929484) Show SMILES ONC(=O)CCCCCn1cc(nn1)-c1ccc2ncnc(Nc3cccc(Cl)c3F)c2c1 Show InChI InChI=1S/C22H21ClFN7O2/c23-16-5-4-6-18(21(16)24)27-22-15-11-14(8-9-17(15)25-13-26-22)19-12-31(30-28-19)10-3-1-2-7-20(32)29-33/h4-6,8-9,11-13,33H,1-3,7,10H2,(H,29,32)(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Tsinghua University Curated by ChEMBL					Assay Description Inhibition of HDAC1 (unknown origin) using acetylated peptide substrate preincubated for 15 mins followed by substrate addition measured after 60 min...				Bioorg Med Chem 25: 27-37 (2017) Article DOI: 10.1016/j.bmc.2016.10.006 BindingDB Entry DOI: 10.7270/Q22N548X
					More data for this Ligand-Target Pair