BDBM50205640 CHEMBL3901407

SMILES: Cc1cc(C)c(CNC(=O)c2cc(cc3N(CCc23)C2CCCC2)C#N)c(=O)[nH]1

InChI Key: InChIKey=WEWUYFKALGFFAR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50205640   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50205640 (CHEMBL3901407) Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3N(CCc23)C2CCCC2)C#N)c(=O)[nH]1 Show InChI InChI=1S/C23H26N4O2/c1-14-9-15(2)26-23(29)20(14)13-25-22(28)19-10-16(12-24)11-21-18(19)7-8-27(21)17-5-3-4-6-17/h9-11,17H,3-8,13H2,1-2H3,(H,25,28)(H,26,29)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	571	n/a	n/a	n/a	n/a	n/a	n/a
Integral BioSciences Pvt. Ltd. Curated by ChEMBL					Assay Description Inhibition of human wild type EZH2 using histone H3 as substrate after 1 hr in presence of 3H-SAM by filter paper detection analysis				Bioorg Med Chem Lett 27: 217-222 (2017) Article DOI: 10.1016/j.bmcl.2016.11.080 BindingDB Entry DOI: 10.7270/Q2S46TZW
					More data for this Ligand-Target Pair