BDBM50205668 4-(4-methoxyphenyl)-2-methyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine::CHEMBL238052

SMILES: COc1ccc(cc1)C1CN(C)Cc2cc(OCCCN3CCCCC3)ncc12

InChI Key: InChIKey=PRLJSGHDMGISHB-UHFFFAOYSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50205668   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50205668 (4-(4-methoxyphenyl)-2-methyl-7-(3-(piperidin-1-yl)...) Show SMILES COc1ccc(cc1)C1CN(C)Cc2cc(OCCCN3CCCCC3)ncc12 |w:8.8| Show InChI InChI=1S/C24H33N3O2/c1-26-17-20-15-24(29-14-6-13-27-11-4-3-5-12-27)25-16-22(20)23(18-26)19-7-9-21(28-2)10-8-19/h7-10,15-16,23H,3-6,11-14,17-18H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development L.L.C. Curated by ChEMBL					Assay Description Binding affinity at human histamine H3				Bioorg Med Chem Lett 17: 5325-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.017 BindingDB Entry DOI: 10.7270/Q24749K4
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50205668 (4-(4-methoxyphenyl)-2-methyl-7-(3-(piperidin-1-yl)...) Show SMILES COc1ccc(cc1)C1CN(C)Cc2cc(OCCCN3CCCCC3)ncc12 |w:8.8| Show InChI InChI=1S/C24H33N3O2/c1-26-17-20-15-24(29-14-6-13-27-11-4-3-5-12-27)25-16-22(20)23(18-26)19-7-9-21(28-2)10-8-19/h7-10,15-16,23H,3-6,11-14,17-18H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development L.L.C. Curated by ChEMBL					Assay Description Displacement of N-[3H]alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells				Bioorg Med Chem Lett 17: 2566-9 (2007) Article DOI: 10.1016/j.bmcl.2007.02.006 BindingDB Entry DOI: 10.7270/Q2TX3F2S
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50205668 (4-(4-methoxyphenyl)-2-methyl-7-(3-(piperidin-1-yl)...) Show SMILES COc1ccc(cc1)C1CN(C)Cc2cc(OCCCN3CCCCC3)ncc12 |w:8.8| Show InChI InChI=1S/C24H33N3O2/c1-26-17-20-15-24(29-14-6-13-27-11-4-3-5-12-27)25-16-22(20)23(18-26)19-7-9-21(28-2)10-8-19/h7-10,15-16,23H,3-6,11-14,17-18H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	34	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development L.L.C. Curated by ChEMBL					Assay Description Binding affinity to rat SERT				Bioorg Med Chem Lett 17: 2566-9 (2007) Article DOI: 10.1016/j.bmcl.2007.02.006 BindingDB Entry DOI: 10.7270/Q2TX3F2S
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50205668 (4-(4-methoxyphenyl)-2-methyl-7-(3-(piperidin-1-yl)...) Show SMILES COc1ccc(cc1)C1CN(C)Cc2cc(OCCCN3CCCCC3)ncc12 |w:8.8| Show InChI InChI=1S/C24H33N3O2/c1-26-17-20-15-24(29-14-6-13-27-11-4-3-5-12-27)25-16-22(20)23(18-26)19-7-9-21(28-2)10-8-19/h7-10,15-16,23H,3-6,11-14,17-18H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	107	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development L.L.C. Curated by ChEMBL					Assay Description Binding affinity at human SERT				Bioorg Med Chem Lett 17: 5325-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.017 BindingDB Entry DOI: 10.7270/Q24749K4
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50205668 (4-(4-methoxyphenyl)-2-methyl-7-(3-(piperidin-1-yl)...) Show SMILES COc1ccc(cc1)C1CN(C)Cc2cc(OCCCN3CCCCC3)ncc12 |w:8.8| Show InChI InChI=1S/C24H33N3O2/c1-26-17-20-15-24(29-14-6-13-27-11-4-3-5-12-27)25-16-22(20)23(18-26)19-7-9-21(28-2)10-8-19/h7-10,15-16,23H,3-6,11-14,17-18H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	107	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development L.L.C. Curated by ChEMBL					Assay Description Binding affinity to human SERT				Bioorg Med Chem Lett 17: 2566-9 (2007) Article DOI: 10.1016/j.bmcl.2007.02.006 BindingDB Entry DOI: 10.7270/Q2TX3F2S
					More data for this Ligand-Target Pair