BDBM50205865 (R)-7-chloro-10-ethyl-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one::CHEMBL223466

SMILES: CCc1ccc(Cl)c2C(=O)N3CCNC[C@H]3c12

InChI Key: InChIKey=JGSLSPNOXHERQP-JTQLQIEISA-N

Data: 3 KI  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50205865   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50205865 ((R)-7-chloro-10-ethyl-1,3,4,10b-tetrahydropyrazino...) Show SMILES CCc1ccc(Cl)c2C(=O)N3CCNC[C@H]3c12 Show InChI InChI=1S/C13H15ClN2O/c1-2-8-3-4-9(14)12-11(8)10-7-15-5-6-16(10)13(12)17/h3-4,10,15H,2,5-7H2,1H3/t10-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	425	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]DOI from human recombinant 5HT2C expressed in HEK293E cells				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50205865 ((R)-7-chloro-10-ethyl-1,3,4,10b-tetrahydropyrazino...) Show SMILES CCc1ccc(Cl)c2C(=O)N3CCNC[C@H]3c12 Show InChI InChI=1S/C13H15ClN2O/c1-2-8-3-4-9(14)12-11(8)10-7-15-5-6-16(10)13(12)17/h3-4,10,15H,2,5-7H2,1H3/t10-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	547	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50205865 ((R)-7-chloro-10-ethyl-1,3,4,10b-tetrahydropyrazino...) Show SMILES CCc1ccc(Cl)c2C(=O)N3CCNC[C@H]3c12 Show InChI InChI=1S/C13H15ClN2O/c1-2-8-3-4-9(14)12-11(8)10-7-15-5-6-16(10)13(12)17/h3-4,10,15H,2,5-7H2,1H3/t10-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.42E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]DOI from human recombinant 5HT2A expressed in HEK293E cells				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50205865 ((R)-7-chloro-10-ethyl-1,3,4,10b-tetrahydropyrazino...) Show SMILES CCc1ccc(Cl)c2C(=O)N3CCNC[C@H]3c12 Show InChI InChI=1S/C13H15ClN2O/c1-2-8-3-4-9(14)12-11(8)10-7-15-5-6-16(10)13(12)17/h3-4,10,15H,2,5-7H2,1H3/t10-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	46	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50205865 ((R)-7-chloro-10-ethyl-1,3,4,10b-tetrahydropyrazino...) Show SMILES CCc1ccc(Cl)c2C(=O)N3CCNC[C@H]3c12 Show InChI InChI=1S/C13H15ClN2O/c1-2-8-3-4-9(14)12-11(8)10-7-15-5-6-16(10)13(12)17/h3-4,10,15H,2,5-7H2,1H3/t10-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	274	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50205865 ((R)-7-chloro-10-ethyl-1,3,4,10b-tetrahydropyrazino...) Show SMILES CCc1ccc(Cl)c2C(=O)N3CCNC[C@H]3c12 Show InChI InChI=1S/C13H15ClN2O/c1-2-8-3-4-9(14)12-11(8)10-7-15-5-6-16(10)13(12)17/h3-4,10,15H,2,5-7H2,1H3/t10-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.28E+3	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair