BDBM50206278 4-(4-(2-aminopropan-2-yl)phenyl)-5-chloro-N-(4-(2-(4-methylpiperazin-1-yl)ethyl)phenyl)pyrimidin-2-amine::CHEMBL392306

SMILES: CN1CCN(CCc2ccc(Nc3ncc(Cl)c(n3)-c3ccc(cc3)C(C)(C)N)cc2)CC1

InChI Key: InChIKey=YDKJOUUUDAWZQE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50206278   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50206278 (4-(4-(2-aminopropan-2-yl)phenyl)-5-chloro-N-(4-(2-...) Show SMILES CN1CCN(CCc2ccc(Nc3ncc(Cl)c(n3)-c3ccc(cc3)C(C)(C)N)cc2)CC1 Show InChI InChI=1S/C26H33ClN6/c1-26(2,28)21-8-6-20(7-9-21)24-23(27)18-29-25(31-24)30-22-10-4-19(5-11-22)12-13-33-16-14-32(3)15-17-33/h4-11,18H,12-17,28H2,1-3H3,(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibiton of VEGFR2				Bioorg Med Chem Lett 17: 2179-83 (2007) Article DOI: 10.1016/j.bmcl.2007.01.086 BindingDB Entry DOI: 10.7270/Q2CR5T2B
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM50206278 (4-(4-(2-aminopropan-2-yl)phenyl)-5-chloro-N-(4-(2-...) Show SMILES CN1CCN(CCc2ccc(Nc3ncc(Cl)c(n3)-c3ccc(cc3)C(C)(C)N)cc2)CC1 Show InChI InChI=1S/C26H33ClN6/c1-26(2,28)21-8-6-20(7-9-21)24-23(27)18-29-25(31-24)30-22-10-4-19(5-11-22)12-13-33-16-14-32(3)15-17-33/h4-11,18H,12-17,28H2,1-3H3,(H,29,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.61E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of CDK1				Bioorg Med Chem Lett 17: 2179-83 (2007) Article DOI: 10.1016/j.bmcl.2007.01.086 BindingDB Entry DOI: 10.7270/Q2CR5T2B
					More data for this Ligand-Target Pair