BDBM50207314 CHEMBL3971200

SMILES: CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(F)cc1

InChI Key: InChIKey=RBCUOKGPVVSZPC-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50207314   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GABA-A receptor; alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50207314 (CHEMBL3971200) Show SMILES CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(F)cc1 Show InChI InChI=1S/C18H18FN3O/c1-12-4-9-16-20-18(13-5-7-14(19)8-6-13)15(22(16)11-12)10-17(23)21(2)3/h4-9,11H,10H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	238	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Positive allosteric modulation of human recombinant GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells assessed as potentiation of of GABA i...				Eur J Med Chem 124: 456-467 (2016) Article DOI: 10.1016/j.ejmech.2016.08.059 BindingDB Entry DOI: 10.7270/Q22B911Z
					More data for this Ligand-Target Pair