BDBM50207666 CHEMBL3892508

SMILES: COc1cccc(CN([C@H](Cc2ccccc2)C(N)=O)C(=O)c2cccs2)c1

InChI Key: InChIKey=XQTCHAKFHLUIGH-LJQANCHMSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50207666   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily M member 8 (TRPM8) (Homo sapiens (Human))	BDBM50207666 (CHEMBL3892508) Show SMILES COc1cccc(CN([C@H](Cc2ccccc2)C(N)=O)C(=O)c2cccs2)c1 |r| Show InChI InChI=1S/C22H22N2O3S/c1-27-18-10-5-9-17(13-18)15-24(22(26)20-11-6-12-28-20)19(21(23)25)14-16-7-3-2-4-8-16/h2-13,19H,14-15H2,1H3,(H2,23,25)/t19-/m1/s1	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...				Bioorg Med Chem 25: 727-742 (2017) Article DOI: 10.1016/j.bmc.2016.11.049 BindingDB Entry DOI: 10.7270/Q2445PF7
					More data for this Ligand-Target Pair