BDBM50208219 (E)-2-(4-methoxystyrylamino)-1-(5-chlorobenzo[b]thiophen-3-yl)-2-oxoethylphosphonic acid::CHEMBL223014

SMILES: COc1ccc(C=CNC(=O)C(c2csc3ccc(Cl)cc23)P(O)(O)=O)cc1

InChI Key: InChIKey=ROERCQZZPQATNB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50208219   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Homo sapiens (Human))	BDBM50208219 ((E)-2-(4-methoxystyrylamino)-1-(5-chlorobenzo[b]th...) Show SMILES COc1ccc(C=CNC(=O)C(c2csc3ccc(Cl)cc23)P(O)(O)=O)cc1 |w:6.5| Show InChI InChI=1S/C19H17ClNO5PS/c1-26-14-5-2-12(3-6-14)8-9-21-19(22)18(27(23,24)25)16-11-28-17-7-4-13(20)10-15(16)17/h2-11,18H,1H3,(H,21,22)(H2,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of human skin chymase				J Med Chem 50: 1727-30 (2007) Article DOI: 10.1021/jm0700619 BindingDB Entry DOI: 10.7270/Q26W99RF
					More data for this Ligand-Target Pair